Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STT3B contributors: mct - updated : 09-01-2019
HGNC name STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
HGNC id 30611
Corresponding disease
CDG1X congenital disorder of glycosylation, type I X
Location 3p23      Physical location : 31.574.490 - 31.677.554
Synonym name
  • homolog of yeast STT3 gene
  • source of immunodominant MHC-associated peptides
  • dolichyl-diphosphooligosaccharide--protein
    • Synonym symbol(s) SIMP, FLJ90106, STT3-B, CDG1X, FLJ90106
    EC.number 2.4.1.119/2.4.99.18
    DNA
    TYPE functioning gene
    STRUCTURE 103.07 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2481 93 826 - 2003 12887896
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids
    • HOMOLOGY
    interspecies ortholog to murine Simp
    Homologene
    FAMILY
  • STT3 family
    • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may have an oligosaccharyltransferase activity
  • RPN1 isoform, required for efficient cotranslational glycosylation of an acceptor site adjacent to the N-terminal signal sequence of a secreted protein
  • efficiently mediates posttranslational glycosylation of a C-terminal glycosylation site in an unfolded protein
  • distinct and complementary roles for the RPN1 isoforms STT3A, STT3B allowing sequential scanning of polypeptides for acceptor sites to insure the maximal efficiency of N-glycosylation
  • STT3B-dependent posttranslational N-glycosylation is part of a triage-salvage system recognizing cryptic N-glycosylation sites of secretory proteins to preserve protein homeostasis
  • one prominent role of the STT3B complex is to mediate glycosylation of sequons that are skipped by the STT3A complex, including those at the extreme C terminus of proteins
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • MAGT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • robust and specific physical interaction between KRTCAP2 and STT3A, and revealed weaker associations with both STT3B and DDOST
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1X
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS