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FLASH GENE
Symbol STT3B contributors: mct - updated : 25-04-2012
HGNC name STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
HGNC id 30611
Location 3p24.1      Physical location : 31.574.490 - 31.677.554
Synonym name
  • homolog of yeast STT3 gene
  • source of immunodominant MHC-associated peptides
  • dolichyl-diphosphooligosaccharide--protein
    • Synonym symbol(s) SIMP, FLJ90106, STT3-B
    EC.number 2.4.1.119
    DNA
    TYPE functioning gene
    STRUCTURE 103.07 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2481 93 826 - 2003 12887896
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids
    • HOMOLOGY
    interspecies ortholog to murine Simp
    Homologene
    FAMILY
  • STT3 family
    • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may have an oligosaccharyltransferase activity
  • RPN1 isoform, required for efficient cotranslational glycosylation of an acceptor site adjacent to the N-terminal signal sequence of a secreted protein
  • efficiently mediates posttranslational glycosylation of a C-terminal glycosylation site in an unfolded protein
  • distinct and complementary roles for the RPN1 isoforms STT3A, STT3B allowing sequential scanning of polypeptides for acceptor sites to insure the maximal efficiency of N-glycosylation
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS