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FLASH GENE

Symbol

STT3A

contributors: mct - updated : 09-01-2019

HGNC name	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
HGNC id	6172

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDG1W congenital disorder of glycosylation, type I W
Location	11q24.2      Physical location : 125.462.738 - 125.491.280
Genatlas name	oligosaccharyl transferase STT3A (staurosporine and temperature sensitive 3A) subunit homolog
Synonym name	integral membrane protein 1
Synonym symbol(s)	TMC, STT3, ITM1, FLJ27038, MGC9042
EC.number	2.4.1.119/2.4.99.18

DNA

TYPE	like-sequence
STRUCTURE	29.96 kb     18 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152713 18 - 2803 NP_689926 - 705 - 2003 12887896 NM_001278503 19 - 4332 NP_001265432 - 705 - 2003 12887896 NM_001278504 17 splicing 4121 NP_001265433 - 613 - 2003 12887896

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   mouth tongue     highly Endocrine adrenal gland       highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

13 transmembrane domains, consistent with the structure of the bacterial homolog of STT3 and setting the stage for future combined efforts to interrogate this fascinating system

HOMOLOGY

interspecies

homolog to murine integral protein B5

Homologene

FAMILY

STT3 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	involved in protein glycosylation
	either required for the assembly of the oligosaccharyl transferase (otase) complex or required in substochiometrix amounts for otase activity
	RPN1 isoform, primarily responsible for cotranslational glycosylation of the nascent polypeptide as it enters the lumen of the endoplasmic reticulum
	distinct and complementary roles for the RPN1 isoforms STT3A, STT3B allowing sequential scanning of polypeptides for acceptor sites to insure the maximal efficiency of N-glycosylation
	encodes the catalytic subunit of the STT3A-containing oligosaccharyltransferase (OST) complex, essential for protein N-glycosylation (PMID;

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	robust and specific physical interaction between KRTCAP2 and STT3A, and revealed weaker associations with both STT3B and DDOST
	KRTCAP2 acts to selectively enhance the oligosaccharyltransferase-dependent processing of specific protein precursors, most likely co-translational substrates of STT3A-containing complexes
	one prominent role of the STT3B complex is to mediate glycosylation of sequons that are skipped by the STT3A complex, including those at the extreme C terminus of proteins
	KRTCAP2 and OSTC are responsible for mediating the interaction between the protein translocation channel and the STT3A complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG1W

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	putative marker for characterization of follicular thyroid neoplasms
Therapy target

ANIMAL & CELL MODELS