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FLASH GENE
Symbol STS contributors: mct/npt - updated : 27-01-2010
HGNC name steroid sulfatase (microsomal), isozyme S
HGNC id 11425
Corresponding disease
DELXPM chromosome Xp terminal deletion in males
SSDI X-linked ichthyosis
Location Xp22.31      Physical location : 7.137.471 - 7.272.680
Synonym name
  • arylsulfatase
  • estrone sulfatase
  • steryl-sulfate sulfohydrolase
  • steroid sulfatase (microsomal), arylsulfatase C, isozyme S
  • arylsulfatase C
  • estrone sulfatase
  • Synonym symbol(s) ARSC1, SSDD, ARSC, ASC, ES, XLI
    EC.number 3.1.6.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text
  • X-linked, escaping inactivation
  • flanked in both sides by a repetitive sequence CRI-S232 which includes a VCX sequence
  • STRUCTURE 135.21 kb     10 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see CDPX1 , PRPS2 , KAL1 KAL1
    Physical map
    XG Xp22.32 Xg blood group (pseudoautosomal boundary-divided on the X chromosome) GYG2 Xp22.3 glycogenin 2 ARSD Xp22.3 arylsulfatase D ARSE Xp22.32 arylsulfatase E (chondrodysplasia punctata 1) LOC347527 Xp22.33 similar to arylsulfatase ARSF Xp22.32 arylsulfatase F DKFZp564I1922 Xp22.33 adlican ASSP4 Xpter-p22 argininosuccinate synthetase pseudogene 4 PRKX Xp22.3 protein kinase, X-linked LOC392423 X similar to ubiquitin and ribosomal protein S27a precursor; ubiquitin carboxyl extension protein 80; 40S ribosomal protein S27a; ubiquitin; ubiquitin-CEP80 LOC347381 Xp22.33 similar to Trifunctional enzyme beta subunit, mitochondrial precursor (TP-beta) NLGN4 Xp22.33 neuroligin 4 LOC392424 X similar to ribosomal protein S5; 40S ribosomal protein S5 VCX-8r Xp22 variable charge protein on X with eight repeats LOC392425 X similar to bA92K2.2 (similar to ubiquitin) FAM16AX Xp22.3 family with sequence similarity 16, member A, X-linked STS Xp22.32 steroid sulfatase (microsomal), arylsulfatase C, isozyme S VCX Xp22.3 variable charge, X chromosome DXS1283E Xp22.3 GS2 gene VCX-2r Xp22.32 variable charge protein on X with two repeats KAL1 Xp22.32 Kallmann syndrome 1 sequence FAM9A Xp22.32 family with sequence similarity 9, member A LOC392426 X similar to Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1) FLJ40182 Xp22.32 hypothetical protein FLJ40182 LOC392427 X similar to chromodomain protein, Y chromosome-like isoform a; CDY-like, autosomal; testis-specific chromodomain Y-like protein TBL1X Xp22.3 transducin (beta)-like 1X-linked GPR143 APXL Xp22.31 apical protein-like (Xenopus laevis) KIAA1280 Xp22.32 KIAA1280 protein CLCN4 Xp22.31 chloride channel 4 MID1 Xp22.3 midline 1 (Opitz/BBB syndrome) HCCS Xp22.3-p22.2 holocytochrome c synthase (cytochrome c heme-lyase) ARHGAP6 Xp22.31 Rho GTPase activating protein 6 AMELX Xp22.31 amelogenin (X chromosome, amelogenesis imperfecta 1)
    RNA
    TRANSCRIPTS type messenger
    text STS expression, in different human tissues, could be regulated by at least six different promoters associated with alternative first exon (Nardi 2009)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6377 - 583 - Valle (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemplacenta  highly
     female systemovary   
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • trypsin domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • sulfatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nuclear envelope
    text membrane-bound microsomal (Valle 2007)
    basic FUNCTION
  • desulphating a number of 3beta-hydroxysteroid sulphates
  • catalyzing the conversion of sulfated steroid precursors to estrogens during pregnancy
  • playing a crucial role in the intra-mitochondrial movement of cholesterol
  • may play a role in susceptibility for attention deficit hyperactivity disorder (Brookes 2008)
  • membrane-bound microsomal enzyme that hydrolyzes various alkyl and aryl steroid sulfates (Nardi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per subunit
  • protein
  • increasing STAR protein expression level and stimulating steroid production
  • cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) SSDI , DELXPM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial carcinomas
    Susceptibility to attention deficit hyperactivity disorder (Brookes 2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS