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FLASH GENE

Symbol

STRN4

contributors: mct - updated : 18-01-2011

HGNC name	striatin, calmodulin binding protein 4
HGNC id	15721

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.32      Physical location : 47.222.769 - 47.249.720
Synonym name	zinedin
Synonym symbol(s)	ZIN, zinedin, FLJ35594

DNA

TYPE	functioning gene
STRUCTURE	26.95 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

in close proximity to CALM3

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001039877 18 - 3242 NP_001034966 - 760 - - NM_013403 18 - 3221 NP_037535 - 753 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Lymphoid/Immune spleen           thymus         Nervous brain         Homo sapiens   ganglia sensory ganglia dorsal root     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative caveolin -binding domain
	a coiled-coil structure, playing an essential role in the targeting of STRN3 within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
	a Ca2+/calmodulin binding domain and eight (?seven) WD40 repeats in the C terminal region

HOMOLOGY

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	membrane -bound

basic FUNCTION	putative signaling and scaffolding protein
	intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
	multimodular WD-repeat, calmodulin and calveolin-binding protein
	PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases

INTERACTION

DNA

RNA

small molecule

protein	calmodulin, Ca2+ dependent, caveolin
	STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
	MINK1 directly interacted with STRN4 (STRN4 reduced MINK1 activity in the presence of catalytic and structural subunits of PPP2CA)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS