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FLASH GENE
Symbol STRN3 contributors: mct - updated : 18-01-2011
HGNC name striatin, calmodulin binding protein 3
HGNC id 15720
Location 14q12      Physical location : 31.363.004 - 31.495.607
Synonym name
  • nuclear autoantigen
  • cell cycle S/G2 nuclear autoantigen
  • cell cycle autoantigen SG2NA
  • striatin-3
  • Synonym symbol(s) SG2NA, GS2NA, STR3
    DNA
    TYPE functioning gene
    STRUCTURE 132.00 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located in close proximity to CALM1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3981 77.7 713 brain, skeletal muscle 2000 10748158
    also called SGN2A alpha
    - - 4233 - 797 - 2000 10748158
    also called SGN2A beta
    - - - 94 - brain, cerebellum, heart, skeletal muscle, lung 2000 10748158
    - - - 112 - brain, cerebellum 2000 10748158
    - - - 102 - brain, cerebellum 2000 10748158
    - - - - - uterus 2008 18434427
  • associate with estrogen receptor-alpha (ESR1) in a ligand-dependent manner
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain     Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    Nervousperipherous    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a caveolin -binding domain
  • a coiled-coil structure, playing an essential role in the targeting of STRN3 within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
  • a Ca2+/calmodulin binding domain
  • six WD40 repeats in the C terminal region
  • HOMOLOGY
    interspecies homolog to murine Strn3
    Homologene
    FAMILY
  • striatin family of WD-40 repeat proteins
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text cytosolic and membrane bound forms
    basic FUNCTION
  • putative signaling and scaffolding protein
  • intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
  • multimodular WD-repeat, calmodulin and calveolin-binding protein
  • PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with STRN and protein phosphatase A heterodimer (PPP2R2A/C)
  • STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of calmodulin, Ca2+ dependent
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS