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FLASH GENE
Symbol STRN contributors: mct - updated : 18-01-2011
HGNC name striatin, calmodulin binding protein
HGNC id 11424
Location 2p22.2      Physical location : 37.075.472 - 37.193.615
Synonym name striatin
Synonym symbol(s) MGC125642, SG2NA
DNA
TYPE functioning gene
STRUCTURE 118.14 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MRPL50P1 2p22.3 mitogen-activated protein kinase kinase kinase kinase 3 CRIM1 2p21 cysteine-rich motor neuron 1 FEZ2 2p21 fasciculation and elongation protein zeta 2 (zygin II) VIT 2p22-p21 vitrin STRN 2p22-p21 striatin, calmodulin binding protein KIAA1414 2p22.3 KIAA1414 protein FLJ38348 2p22.3 hypothetical protein FLJ38348 PRKR 2p22-p21 protein kinase, interferon-inducible double stranded RNA dependent LOC391365 2 similar to sulfotransferase CBF2 2p23.1 similar to sulfotransferase PRO1853 2p22.3 hypothetical protein PRO1853 PRKCN 2p21 protein kinase C, nu QPCT 2p22.3 glutaminyl-peptide cyclotransferase (glutaminyl cyclase) CDC42EP3 2p21 CDC42 effector protein (Rho GTPase binding) 3 LOC344382 2p22.3 similar to UNR-interacting protein (WD-40 repeat protein PT-WD) (MAP activator with WD repeats) FLJ32954 2p22.3 hypothetical protein FLJ32954 CYP1B1 2p21 cytochrome P450, family 1, subfamily B, polypeptide 1 MGC34824 2p22.3 hypothetical protein MGC34824 LOC391366 2 similar to ribosomal protein L7 LOC391367 2 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ARL6IP2 2p22.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388940 2 LOC388940 LOC220717 2p22.3 similar to BLOCK 23 LOC92906 2p22.3 hypothetical protein BC008217 LOC130589 SFRS7 2p22-p21 splicing factor, arginine/serine-rich 7, 35kDa GEMIN6 2p22.3 gem (nuclear organelle) associated protein 6 DHX57 2p22.3 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 ASSP2 6q14.3-q15 argininosuccinate synthetase pseudogene 2 LOC387626 2 hypothetical gene supported by NM_144995 MOPT  protein containing single MORN motif in testis SOS1 2p22-p21 son of sevenless homolog 1 (Drosophila) LOC344387 2p22.3 similar to cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K3 2p22.2 mitogen-activated protein kinase kinase kinase kinase 3
regionally located in close proximity to CALM2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3479 86.1 780 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain     Homo sapiens
 ganglia     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousperipherous    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a caveolin -binding domain
  • a coiled-coil structure, playing an essential role in the targeting of STRN within spines, and also crucial for the homo- and hetero-oligomerization of these proteins
  • a Ca2+/calmodulin binding domain and eight (?seven) WD40 repeats in the C terminal region
  • HOMOLOGY
    interspecies homolog to murine Strn
    Homologene
    FAMILY
  • striatin family of WD-40 repeat proteins
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic and membrane bound somatodendritic compartments
    basic FUNCTION
  • may function as scaffolding or signaling protein and may
  • play a role in dendritic Ca(2+) signaling
  • intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling
  • molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
  • molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways
  • multimodular WD-repeat, calmodulin and calveolin-binding protein
  • PDCD10 and striatins exhibit opposing functions on the targeting of MST4 to the Golgi and Golgi positioning
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with GS2NA and protein phosphatase A heterodimer (PPP2PA/C)
  • STRIPAK contains the PPP2CA, the striatins (STRN, STRN3, STRN4), MOB4, FAM40A and FAM40B, the cerebral cavernous malformation 3 (CCM3) protein, and members of the germinal center kinase III family of Ste20 kinases
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • calmodulin binding, caveolin
  • directly binds to AAs 183-253 of ESR1, targets ESR1 to the cell membrane, and serves as a scaffold for the formation of an ESR1-Galphai complex
  • STRN, STRN32, STRN4 binds directly to PPP2CA and PDCD10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS