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FLASH GENE
Symbol STRAP contributors: mct/npt - updated : 09-11-2011
HGNC name serine/threonine kinase receptor associated protein
HGNC id 30796
Location 12p12.3      Physical location : 16.035.287 - 16.056.403
Synonym name unr-interacting protein
Synonym symbol(s) MAWD, PTWD, UNRIP, PT-WD
DNA
TYPE functioning gene
STRUCTURE 21.12 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1924 - 350 - 2005 16159890
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx   
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WD-40 repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat STRAP family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text localizes predominantly to the cytoplasm and is absent from gems/Cajal bodies
    basic FUNCTION
  • involved in tumor progression
  • playing a crucial role in the intracellular distribution of the SMN complex
  • having an oncogenic function
  • having a TGF-beta-independent function and a role in the maintenance of mesenchymal morphology
  • potential role for STRAP phosphorylation in MAP3K5 activity regulation, and can act as a negative regulator of MAP3K5
  • functions as a regulator of both TGFBand TP53 signaling
  • regulates JUN stability by decreasing the ubiquitylation and proteosomal degradation of JUN
  • increases expression of the AP-1 target gene, cyclin D1, and promotes cell autonomous growth
  • can reciprocally affect the signal transduction pathways mediated by its binding partner
  • regulates signaling by affecting components of the MAPK signaling pathways
  • regulates JUN expression by inhibiting the ubiquitylation and degradation of JUN
  • may promote growth and tumorigenicity by regulating the TGFB, ERK, and JUN signaling pathways
  • role of STRAP in regulating GSK3B function and NOTCH3 stabilization
  • is a novel regulator of the coordinated translation of collagen mRNAs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with SMN complex
  • first component of the U snRNP assembly machinery that associates with the SMN complex in a compartment-specific way
  • STRAP, GSK3B and Axin form a ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with SMN complex, to influencing intracellular localization of SMN1
  • interplay between PPM1G and STRAP determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex
  • directly targeted by the DNA damage signalling pathway where phosphorylation by ATM kinase facilitates nuclear accumulation
  • associates with both TGF-beta receptors and synergizes with the inhibitory SMAD, SMAD7, in the negative regulation of TGF-beta-induced transcription
  • interacts with transforming growth factor beta (TGF-beta) receptors and inhibits TGF-beta signaling
  • interacting partner of MAP3K5
  • MYBL2 is a new STRAP-interacting protein, and an N-terminal DNA-binding domain and an area (AAs 373-468) between the acidic and conserved regions of MYBL2 mediate the MYBL2ĚSTRAP interaction
  • binding of GSK3B with STRAP, through its WD40 domains
  • also binds intracellular fragment of Notch3 (ICN3) through the ankyrin repeat region, and this binding is enhanced in a proteasomal inhibition-dependent manner
  • tethered to collagen mRNAs by interaction with LARP6
  • cell & other
    REGULATION
    activated by MYBL2 acting as a positive regulator of STRAP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    detected in human lung, colon, and breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS