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FLASH GENE
Symbol STRA8 contributors: mct/npt/pgu - updated : 25-03-2021
HGNC name stimulated by retinoic acid gene 8 homolog
HGNC id 30653
Location 7q33      Physical location : 134.916.730 - 134.943.242
DNA
TYPE functioning gene
STRUCTURE 26.51 kb     9 Exon(s)
regulatory sequence Promoter
text structure
  • TAF4B occupies the proximal promoters of many essential meiosis and oogenesis regulators, including STRA8, DAZL, FIGLA, and NOBOX, and is required for their proper expression
  • SETD8 protein directly bound to the proximal promoter of the STRA8 gene
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 993 46 330 - 2009 19805549
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale system     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text developing male gonad , and highest expression in the fetal ovary
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttles between nucleus and cytoplasm
    basic FUNCTION
  • may play a role in the premeiotic phase of spermatogenesis
  • in preleptotene spermatocytes, STRA8 is involved in the process that leads to stable commitment to the meiotic cell cycle
  • can exert important functions in the nucleus rather than in the cytoplasm as believed previously, likely depending on the cell type and regulated by its nuclear-cytoplasmic shuttling
  • active import of STRA8 into the nucleus raises the little considered possibility that this protein may act as transcription factor or cooperate with transcription factors in regulating specific gene activities
  • indispensable for meiotic entry in embryonal female and postnatal male germ cells
  • STRA8, previously shown to be required for meiotic initiation, also promotes (but is not strictly required for) spermatogonial differentiation
  • SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells
  • is required for the meiotic initiation of male spermatogenesis
  • STRA8 may likely directly or indirectly inhibit caspases through the AKT1 signaling pathway and ultimately exert an anti&
  • 8209;apoptotic effect in the male reproductive system
  • is an essential gatekeeper of meiotic initiation in vertebrates
  • link between STRA8-mediated autophagy suppression and meiotic initiation
  • STRA8, which is expressed in response to RA, is thought to be a key factor promoting meiotic initiation
  • MEIOSIN acts as a transcription factor together with STRA8, and both factors are critical for driving meiotic gene activation
  • MEIOSIN, in collaboration with STRA8, plays a central role in regulating the mitosis to meiosis germ cell fate decision in mammals
  • retinoic acid (RA) induced gene that plays vital roles in spermatogonial proliferation, differentiation and meiosis
  • STRA8 and SETD8 display a cell cycle-dependent expression pattern in germline cells.
  • STRA8 induces transcriptional changes in germ cells during spermatogonial development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NANOS2
  • interacting with DMRT1 (essential role of DMRT1 in testicular differentiation, including transcriptional repression of the meiotic inducer STRA8)
  • CREBBP and EP300 play distinct roles in RA-mediated STRA8 gene transcription
  • CYP26B1 suppresses two distinct genetic programs induced by RA: a STRA8-dependent meiotic pathway, and a STRA8-independent mitotic pathway
  • SOHLH1 and SOHLH2 directly down-regulate STRA8
  • NR1D1 is a direct target of STRA8 transcriptional repression
  • MEIOSIN is a germ-cell-specific factor that associates with STRA8
  • SETD8 negatively regulated transcriptional activity of the STRA8 promoter
  • STRA8, indirectly, is able to exert a negative control on the SOHLH1-dependent stimulation of KIT expression in late differentiating spermatogonia and preleptotene spermatocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • while spermatogonia from Stra8 knockout mice can ultimately form spermatocytes that fail to complete meiosis, it appears that the defect likely begins as a result of altered messenger RNA levels during spermatogonial differentiation