basic FUNCTION
| may play a role in the premeiotic phase of spermatogenesis |
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in preleptotene spermatocytes, STRA8 is involved in the process that leads to stable commitment to the meiotic cell cycle |
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can exert important functions in the nucleus rather than in the cytoplasm as believed previously, likely depending on the cell type and regulated by its nuclear-cytoplasmic shuttling |
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active import of STRA8 into the nucleus raises the little considered possibility that this protein may act as transcription factor or cooperate with transcription factors in regulating specific gene activities |
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indispensable for meiotic entry in embryonal female and postnatal male germ cells |
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STRA8, previously shown to be required for meiotic initiation, also promotes (but is not strictly required for) spermatogonial differentiation |
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SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells |
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is required for the meiotic initiation of male spermatogenesis |
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STRA8 may likely directly or indirectly inhibit caspases through the AKT1 signaling pathway and ultimately exert an anti& |
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8209;apoptotic effect in the male reproductive system |
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is an essential gatekeeper of meiotic initiation in vertebrates |
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link between STRA8-mediated autophagy suppression and meiotic initiation |
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STRA8, which is expressed in response to RA, is thought to be a key factor promoting meiotic initiation |
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MEIOSIN acts as a transcription factor together with STRA8, and both factors are critical for driving meiotic gene activation |
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MEIOSIN, in collaboration with STRA8, plays a central role in regulating the mitosis to meiosis germ cell fate decision in mammals |
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retinoic acid (RA) induced gene that plays vital roles in spermatogonial proliferation, differentiation and meiosis |
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STRA8 and SETD8 display a cell cycle-dependent expression pattern in germline cells. |
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STRA8 induces transcriptional changes in germ cells during spermatogonial development |