Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

STRA6

contributors: mct/pgu - updated : 22-05-2013

HGNC name	stimulated by retinoic acid gene 6 homolog (mouse)
HGNC id	30650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PAMD pulmonary agenesis, microphthalmia, and diaphragmatic defect
Location	15q24.1      Physical location : 74.471.809 - 74.501.371
Synonym symbol(s)	FLJ12541, PP14296, MCOPS9

DNA

TYPE	functioning gene
STRUCTURE	30.24 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001142617 19 - 2866 NP_001136089 - 667 - 1997 9203140 NM_001142618 19 - 2848 NP_001136090 - 667 - 1997 9203140 NM_001142619 19 - 2839 NP_001136091 - 658 - 1997 9203140 NM_001142620 6 - 1956 NP_001136092 - 159 - 1997 9203140 NM_022369 19 - 2802 NP_071764 - 667 - 1997 9203140 NM_001199040 19 - 2982 NP_001185969 - 704 - 1997 9203140 NM_001199041 19 - 2993 NP_001185970 - 682 - 1997 9203140 NM_001199042 19 - 3097 NP_001185971 - 706 - 1997 9203140

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve cranial nerve     highly Reproductive female system placenta     highly   male system testis     highly Visual eye anterior segment         eye retina

cells

System Cell Pubmed Species Stage Rna symbol Reproductive Sertoli cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

between 8 and 12 transmembrane helices

HOMOLOGY

Homologene

FAMILY

stimulated by retinoic acid (STRA) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	induced mitochondria depolarization and accumulation of reactive oxygen species, and was present not only at the cellular membrane but also in the cytosol

basic FUNCTION	retinol-binding protein receptor may be a component of an as yet unidentified transport machinery
	involved in vitamin A metabolism, and implicated in anophthalmia and microphthalmia developmental abnormalities
	multitransmembrane domain protein, and specific membrane receptor for retinol binding protein (RBP)
	functioning as the high-affinity receptor for plasma retinol binding protein (RBP) and mediates cellular uptake of vitamin A from the vitamin A-RBP complex
	transmembrane receptor involved in vitamin A uptake, a process essential to eye development and growth
	transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also functions as a cytokine receptor which activates JAK/STAT signaling
	appears to be a founding member of a new class of proteins that may be termed "cytokine signaling transporters"
	catalyzes efficient retinol exchange between intracellular RBP1 and extracellular retinol binding protein, even in the presence of holo-RBP
	retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein
	RBP4 and its membrane receptor STRA6 coordinate cellular retinol uptake

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex
	binds to RBP with high affinity and mediates vitamin A uptake into cells
	transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6

cell & other

REGULATION

activated by

DNA damage in a TP53-dependent manner, and it has an important role in cell death responses

ASSOCIATED DISORDERS

corresponding disease(s)

PAMD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS