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FLASH GENE
Symbol STMN4 contributors: - updated : 26-12-2005
HGNC name stathmin-like 4
HGNC id 16078
Location 8p21.1      Physical location : 27.093.815 - 27.115.903
Synonym name stathmin-like-protein RB3
Synonym symbol(s) RB3
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text at least three RB3, RB3', RB3''
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - - 142 - Nakao
slowed microtubule elongation velocity, increased catastrophes, and reduced rescues
- - - - 217 - Nakao
having not only stathmin-like microtubule destabilizing activity but also microtubule-associated protein-like microtubule stabilizing activity
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neurons
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal domain with an hydrophobic extension, membrane-associated domain
  • a coiled-coil region
  • a C terminal stathmin-like domain, which promotes microtubule (MT) catastrophe and/or tubulin sequestering
  • HOMOLOGY
    interspecies homolog to murine Scgn10
    Homologene
    FAMILY SCG10/stathmin family proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • able to depolymerize interphase microtubules when overexpressed
  • playing a role in differentiated neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS