Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STMN1 contributors: shn/mct - updated : 30-03-2016
HGNC name stathmin 1
HGNC id 6510
Location 1p36.11      Physical location : 26.210.677 - 26.233.368
Synonym name
  • prosolin, metablastin, oncoprotein STMN1
  • leukemia-associated phosphoprotein p18 (stathmin)
  • stathmin 1/oncoprotein 18
  • chromosome 1 open reading frame 215
  • oncoprotein 18
  • phosphoprotein 19
  • metablastin
  • Synonym symbol(s) LAP18, SMN, OP18, PP17, PP19, PR22, STN1, LAG, FLJ32206, MGC138869, MGC138870, C1orf215
    DNA
    TYPE functioning gene
    STRUCTURE 22.69 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure Four CCAAT- boxes at positions -980 -745 -599 and -65 relative to the transcriptional start site
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S234 - D1S2885 - STMN1 - D1S455 - D1S2749 - cen
    Physical map
    LOC388606 1 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat RHD 1p36.1 Rhesus blood group, D antigen LOC388607 1 similar to RhCE protein LOC388608 1 similar to mutant membrane protein RhCe FLJ10747 1p36.11 hypothetical protein FLJ10747 ARH MAN1C1 1p35 mannosidase, alpha, class 1C, member 1 SEPN1 1p36.13 selenoprotein N, 1 LOC56181 1p35.3 hypothetical protein RP1-317E23 MGC2603 1p35.3 hypothetical protein MGC2603 MPRA 1p36.11 hypothetical protein MGC2603 FLJ32206 1p35.3 hypothetical protein FLJ32206 STMN1 1p36.11 stathmin 1/oncoprotein 18 LOC388609 1 LOC388609 PAFAH2 1p34.2 platelet-activating factor acetylhydrolase 2, 40kDa EXTL1 1p36.1 exostoses (multiple)-like 1 SLC30A2 1p35.3 solute carrier family 30 (zinc transporter), member 2 RNF28 1p34-p33 ring finger protein 28 LOC149420 1p35.3 casein kinase FLJ14050 1p35.3 hypothetical protein FLJ14050 ZT86 1p35.3 zinc finger protein CNK1 1p35.3 zinc finger protein CATSPER4 1p35.3 cation channel, sperm associated 4 LOC391021 1 similar to secreted acid phosphatase 2 (SAP2) DKFZP434L0117 1p35.3 hypothetical protein DKFZp434L0117 MRPS6P1 1p35 mitochondrial ribosomal protein S6 pseudogene 1 SH3BGRL3 1p35-p34.3 SH3 domain binding glutamic acid-rich protein like 3 SOC 1p35.3 SH3 domain binding glutamic acid-rich protein like 3 CDW52 1p36 CDW52 antigen (CAMPATH-1 antigen) AIM1L 1p35.3 absent in melanoma 1-like MGC33414 1p35.3 hypothetical protein MGC33414 LIN28 1p35.3 lin-28 homolog (C. elegans) DHDDS 1p35.3 dehydrodolichyl diphosphate synthase HMGN2 1p36.1 high-mobility group nucleosomal binding domain 2 RPS6KA1 1p36-p35 ribosomal protein S6 kinase, 90kDa, polypeptide 1
    RNA
    TRANSCRIPTS type messenger
    text
  • two classes resulting from the usage of different polyadenylation sites
  • all variants encode the same protein
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1730 19 149 - 2005 16286011
    5 - 1518 19 149 - 2005 16286011
    differing in the 5' UTR compared to variant 1
    5 - 1542 19 149 - 2005 16286011
    differing in the 5' UTR compared to variant 1
    5 - 2265 19 174 punctate cytoplasmic distribution but more concentrated around the nucleus - highly expressed in the lateral nucleus of the amygdala and in the thalamic and cortical structures 2005 16286011
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   predominantly
    Nervousbrain   highly
    Reproductivefemale systemuterus  moderately
     male systemtestis  moderately
    Urinarybladder   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsensoryolfactory  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    cell lineage
    cell lines neuroendocrine tumor cells
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, S, G2, checkpoint, G2M
    Text
  • olfactory neurons
  • high expression in the developing nervous system (Wen 2010)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain
  • a coiled-coil region
  • a C terminus with the stathmin domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Lag
    ortholog to Stmn1, Rattus Norvegicus
    ortholog to Stmn1, Mus musculus
    ortholog to STMN1, Pan troglodytes
    ortholog to stmn1, Danio rerio
    Homologene
    FAMILY
  • stathmin family
  • CATEGORY regulatory , protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    basic FUNCTION
  • intracellular relay integrating diverse regulatory signals of the cell's environment for regulation of cell proliferation and differentiation
  • able to depolymerize interphase microtubules when overexpressed
  • inhibits apoptosis by acting through a mitochondrial apoptotic pathway
  • regulation of the microtubule filament system by destabilizing microtubules
  • could play a role in regulation of the growth of osteoblast-like cells in response to various hormonal stimuli
  • required for the induction of long-term potentiation in afferent inputs to the amygdala and is essential in regulating both innate and learned fear
  • critical molecular component linking the basolateral complex of the amygdala nuclei-associated neural circuitry with innate parental behaviors and adult social interactions
  • microtubule-destabilizing protein, that promotes microtubule depolymerization by increasing the microtubule catastrophe rate (Wen 2010)
  • possibly a pathogenic factor in SMA, and the disruption of microtubule maintenance may be partly involved in SMA pathogenesis (Wen 2010)
  • is a regulator of the microtubule network during T cell activation
  • role of stathmin in microtubule-dependent control of endothelial permeability
  • regulates mitotic entry, partially via MTs, to control localization and activation of both AURKA and PLK1
  • has a dual function as both an oncogene and a metastasis suppressor
  • might play its oncogenic role by an interaction with NfKB1 pathway
  • stathmin controls likely the transition from neuronal precursors to early postmitotic neurons
  • performs a critical function in cell proliferation by regulating microtubule polymerization
  • mediates hepatocyte resistance to death from oxidative stress by down regulating MAPK8 and maintaining mitochondrial integrity
  • major microtubule-depolymerizing protein, involved in cell cycle progression and cell motility
  • may have an important role in in non-small cell lung cancer (NSCLC) progression and could serve as a potential prognostic marker for patients with NSCLC
  • pivotal inhibitory role for stathmin in classically activated macrophages
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • G2/M transition
  • mitotic spindle organization and biogenesis
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • many different phosphorylated forms observed, depending on specific combinations among the sites which can be phosphorylated
  • MAPK is responsible for the phosphorylation of stathmin in response to NGF
  • required for the induction of long-term potentiation in afferent inputs to the amygdala
  • being essential in regulating both innate and learned fear
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KIST
  • two alpha/beta-tubulin heterodimers
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
  • U2AF homology motif (UHM) kinase 1
  • RB1-inducible coiled-cool 1
  • tumor susceptibility gene 101
  • iInteraction between PTP4A3 and stathmin leads to microtubules destabilization of colorectal cancer (CRC) cells, which contributes to progression and metastasis of CRC
  • interacting with SIVA1 (inhibits STMN1 activity directly as well as indirectly, and via the inhibition of STMN1, SIVA1 enhances the formation of microtubules and impedes focal adhesion assembly, cell migration, and EMT)
  • downregulated by PDEF, suggesting that PDEF may inhibit prostate cancer progression by transcriptional downregulation of oncogenic STMN1 expression
  • STMN1 is a relevant CDKN1B binding partner (cooperates with CDKN1B to control the early phase of G1 to S phase transition and this function may be of particular relevance in the context of tumor progression)
  • cell & other
    REGULATION
    induced by phosphorylation induced by multiple signal transduction pathways
    Other
  • both activation and repression by NF-Y
  • NF-Yis a major transcription factor promoting expression of STMN1
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma, melanoma and acute leukemia
    constitutional       gain of function
    aberrantly upregulated in in SMA, leading to a decreased level of polymerized tubulin, which was correlated with disease severity (Wen 2010)
    tumoral     --over  
    in pancreatic cancer tissues and high expression of stathmin was correlated with vascular emboli, tumor size, and overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SIVA1 and STMN1 may be biomarkers for breast cancer
  • could serve as a potential prognostic marker for patients with in non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    SIVA1 and STMN1 may be therapeutic targets for breast cancer
    neuromuscularlaterale amyotrophy sclerosis 
    inhibition of stathmin expression in SMA diminished the SMA phenotype, these results suggest that microtubule dynamics may be a potential therapeutic target and could provide a novel avenue for SMA therapy
    cancerbrain 
    modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
    ANIMAL & CELL MODELS
  • deficiency in fear processing in stathmin(-/-) female mice leads to improper threat assessment and profound deficiency is observed in maternal behavior as well