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FLASH GENE
Symbol STK38L contributors: mct/ - updated : 31-05-2014
HGNC name serine/threonine kinase 38 like
HGNC id 17848
Location 12p11.23      Physical location : 27.397.077 - 27.478.888
Synonym name
  • related to Ndr protein kinase
  • nuclear Dbf2-related 2
  • NDR2 protein kinase
  • Synonym symbol(s) KIAA0965, NDR2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 81.42 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC121153 12p12.1 similar to Brain protein I3 (pRGR2) LOC387847 12 LOC387847 LRMP 12p12.1 lymphoid-restricted membrane protein LAS1 LOC144363 12p12.1 hypothetical protein LOC144363 KRAS2 12p12.1 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog FLJ36004 12p12.1 hypothetical protein FLJ36004 LOC283347 12p12.1 similar to thymine-DNA glycosylase C12orf2 12p12.3 chromosome 12 open reading frame 2 BHLHB3 12p12.1-p11.23 basic helix-loop-helix domain containing, class B, 3 LOC387848 12 LOC387848 SSPN 12p11.2 sarcospan (Kras oncogene-associated gene) ITPR2 12p11 inositol 1,4,5-triphosphate receptor, type 2 LOC341370 12p12.1 similar to Dag1-prov protein FLJ10637 12p12.1 hypothetical protein FLJ10637 DKFZP564O1863 TM7SF3 12q11.2-q12 transmembrane 7 superfamily member 3 SURB7 12p12.3 SRB7 suppressor of RNA polymerase B homolog (yeast) LOC341371 12p12.1 hypothetical LOC341371 STK38L 12p12.3-p11.22 serine/threonine kinase 38 like ARNTL2 12p11.23-p11.22 aryl hydrocarbon receptor nuclear translocator-like 2 LOC341346 12p12.1 similar to hypothetical protein PPFIBP1 12q14.3 PTPRF interacting protein, binding protein 1 (liprin beta 1) LOC387849 12 similar to RIKEN cDNA 2210417D09 MRPS35 12p11 mitochondrial ribosomal protein S35 KIAA1340 12p12.1 KIAA1340 protein PTHLH 12p11.2 parathyroid hormone-like hormone FLJ11088 12p11.23 GGA binding partner FLJ10462 12p11.23 hypothetical protein FLJ10462 PTX1 12p11.23 PTX1 protein OVCH1 12p11.23 ovochymase 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5110 - 464 - 2004 1506700
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to Ndr protein kinase
    Homologene
    FAMILY
  • AGC Ser/Thr protein kinase family
  • NDR/LATS kinase family
  • CATEGORY enzyme , regulatory , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text excluded from the nucleus and exhibits a punctate cytoplasmic distribution
    basic FUNCTION
  • involved in the regulation of structural processes in differentiating and mature neuronal cells
  • might play a role in the HIV-1 life cycle
  • with STK38, are proapoptotic kinases and key members of the RASSF1/STK4 signaling cascade
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • STK24-STK38/STK38L-CDKN1A axis is an important regulator of G(1)/S progression of mammalian cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MOBKL1B
  • MOBKL1A
  • MOB2 is a negative regulator of STK38/STK38L in biochemical and biological settings
  • binds to and colocalizes with GTP-bound RAB11A and phosphatidylserine (PS) on pericentrosomal vesicles
  • STK38L-mediated RAB8A phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of RAB8A from phosphatidylserine (PS) to EXOC6, thereby promoting local activation of RAB8A and ciliary membrane formation
  • novel function of CCND1 in promoting cell cycle progression by enhancing STK38/STK38L kinase activity independent of CDK4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS