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FLASH GENE
Symbol STK36 contributors: mct - updated : 17-11-2021
HGNC name serine/threonine kinase 36 (fused homolog, Drosophila)
HGNC id 17209
Corresponding disease
ICS49 immotile cilia syndrome 49
Location 2q35      Physical location : 219.536.761 - 219.567.439
Genatlas name Drosophila fused protein homolog
Synonym symbol(s) KIAA1278, FU, DKFZp434N0223
EC.number 2.7.1.37/ 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 30.67 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4873 - 1315 - 2017 28543983
27 - 4810 - 1294 - 2017 28543983
27 - 4793 - 1315 - 2017 28543983
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
 spinal cord    
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one PH domain
HOMOLOGY
interspecies homolog to Drosophila fused protein homolog
Homologene
FAMILY ser/thr protein kinase family, RAC subfamily
CATEGORY enzyme , receptor membrane serine/threonine kinase
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • controling the activity of GLI1 and GLI2 by opposing the effect of SUFU
  • phosphorylating KIF7 and KIF27
  • critical function of STK36 in central pair construction and cilia orientation of motile cilia that line the tracheal and ependymal epithelia
  • conserved function of STK36 in the oviduct
  • STK36 ubiquitination and cleavage is one of the key elements connecting the MID1-PPP2CA protein complex with GLI3 activity control
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI3K)
  • interacting with GLI1, and GLI2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS49
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fu-deficient mouse oviducts uncovers a similar role of Fu in central pair construction and cilia orientation