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FLASH GENE
Symbol STK36 contributors: - updated : 26-03-2005
HGNC name serine/threonine kinase 36 (fused homolog, Drosophila)
HGNC id 17209
Location 2q35      Physical location : 219.536.761 - 219.567.439
Genatlas name Drosophila fused protein homolog
Synonym symbol(s) KIAA1278, FU
EC.number 2.7.1.37
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750 SLC11A1 2q35 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 CTDSP1 2q35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 VIL1 2q35 villin 1 USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39) CRYBA2 2q34-q36 crystallin, beta A2 DKFZp434O0527 2q36.1 hypothetical protein DKFZp434O0527 MGC35338 2q36.1 hypothetical protein MGC35338 IHH 2q35-q36 Indian hedgehog homolog (Drosophila) FLJ12610 2q36.1 hypothetical protein FLJ12610
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
 spinal cord    
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one PH domain
HOMOLOGY
interspecies homolog to Drosophila fused protein homolog
Homologene
FAMILY ser/thr protein kinase family, RAC subfamily
CATEGORY enzyme , receptor membrane serine/threonine kinase
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • controling the activity of GLI1 and GLI2 by opposing the effect of SUFU
  • phosphorylating KIF7 and KIF27
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI3K)
  • interacting with GLI1, and GLI2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS