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FLASH GENE
Symbol STK35 contributors: - updated : 26-10-2004
HGNC name serine/threonine kinase 35
HGNC id 16254
Location 20p13      Physical location : 2.082.527 - 2.129.196
Synonym name
  • CLP-36 interacting kinase
  • PDLIM1-interacting kinase 1
  • Synonym symbol(s) bA550O8.2, Clik1
    EC.number 2.7.1.37, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 45.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Authors GeneMap (99)
    Physical map
    SDCBP2 20p13 syndecan binding protein (syntenin) 2 FLJ20802 20p13 hypothetical protein FLJ20802 FKBP1A 20p13 FK506 binding protein 1A, 12kDa NSFL1C 20p13 NSFL1 (p97) cofactor (p47) PTPNS1L3 20p12.2-13 protein tyrosine phosphatase, non-receptor type substrate 1-like 3 PTPNS1L2 20p13 protein tyrosine phosphatase, non-receptor type substrate 1-like 2 SIRPB1 20p13 signal-regulatory protein beta 1 SIRPB2 20p13 signal-regulatory protein beta 2 LOC391227 20 similar to Signal-regulatory protein beta-2 precursor (SIRP-beta-2) (SIRP-b2) LOC388779 20 LOC388779 PTPNS1 20p13 protein tyrosine phosphatase, non-receptor type substrate 1 PDYN 20p13 prodynorphin RPL7P2 20p13 ribosomal protein L7 pseudogene 2 STK35 20 serine/threonine kinase 35 LOC388780 20 LOC388780 TGM3 20p13 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase) TGM6 20p13 transglutaminase y SNRPB 20p13 small nuclear ribonucleoprotein polypeptides B and B1 MGC10715 20p13 novel C2H2 type zinc finger protein TMC2 20p13 transmembrane, cochlear expressed, 2 NOL5A 20p13 nucleolar protein 5A (56kDa with KKE/D repeat) IDH3B 20p13 isocitrate dehydrogenase 3 (NAD+) beta KIAA1442 20p13 KIAA1442 protein
    regionally located between D20S117 and D20S113
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serine/threonine kinase domain
  • four potential NLS signals
  • a proline-rich region
  • HOMOLOGY
    interspecies homolog to murine 1700054C12Rik
    homolog to rattus LOC311419
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text predominantly nuclear but relocalized to actin stress fibers under PDLIM1 association
    basic FUNCTION
  • protein serine/threonine kinase activity
  • may be a regulator of actin stress fibers in non muscle cells
  • involved in autophagy
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • can interact with PDLIM1/CLP-36 in the cytoplasm
  • cell & other
    REGULATION
    Other autophosphorylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS