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FLASH GENE
Symbol STK33 contributors: mct/npt - updated : 04-09-2009
HGNC name serine/threonine kinase 33
HGNC id 14568
Location 11p15.4      Physical location : 8.413.417 - 8.615.503
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 202.08 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NALP14 11p15.4 NACHT, leucine rich repeat and PYD containing 14 HNRNPG-T 11p15 testes-specific heterogenous nuclear ribonucleoprotein G-T LOC143425 11p15.4 similar to synaptotagmin V UNQ564 11p15.4 MVAL564 PPFIBP2 11p15.5 PTPRF interacting protein, binding protein 2 (liprin beta 2) CYB5R2 11p15.4 cytochrome b5 reductase b5R.2 OVTN 11p15.4 oviductin protease LOC390091 11 similar to seven transmembrane helix receptor LOC390092 11 similar to olfactory receptor MOR204-2 LOC341278 11p15.4 similar to seven transmembrane helix receptor JCG3 11p15.4 olfactory receptor-like protein JCG3 JCG1 11p15.4 olfactory receptor-like protein JCG1 OR5E1P 11p15.5 olfactory receptor, family 5, subfamily E, member 1 pseudogene LOC390093 11 similar to Olfactory receptor 10A6 OR10A3 11p15.4 olfactory receptor, family 10, subfamily A, member 3 NALP10 11p15.4 NACHT, leucine rich repeat and PYD containing 10 EIF3S5 2p16.1 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa TUB 11p15.4 tubby homolog (mouse) RIC3 11p15.4 RIC3 protein LMO1 11p15.3 LIM domain only 1 (rhombotin 1) STK33 11p15.3 serine/threonine kinase 33 KIAA0298 11p15.5-p15.1 serine/threonine kinase 33 LOC283118 11p15.3 hypothetical LOC283118 RPL27A 11p15.5 ribosomal protein L27a ST5 11p15 suppression of tumorigenicity 5 C11orf17 11p15.3 chromosome 11 open reading frame 17 C11orf16 11p15.3 chromosome 11 open reading frame 16 ASCL3 11p15.3 achaete-scute complex (Drosophila) homolog-like 3 C11orf15 11p15.3 chromosome 11 open reading frame 15 NRIP3 11p15.3 nuclear receptor interacting protein 3 SCUBE2 11p15.3 signal peptide, CUB domain, EGF-like 2 FLJ46111 11p15.3 FLJ46111 protein RAB6IP1 11p15.3 RAB6 interacting protein 1 KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2707 - 514 - Mujica (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis  highly
 male systemprostate   
Respiratorylung    
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
Respiratoryalveolar macrophage
Respiratoryepithelial cell
Visualhorizontal association cell
cell lineage
cell lines
fluid/secretion
at STAGE
Text embryonic organs such as heart, brain and spinal cord (Mujica 2005)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • may be involved in protein amino acid phosphorylation
  • involved in the dynamics of the intermediate filament cytoskeleton by phosphorylating vimentin (Brauksiepe 2008)
  • acting as a component of a signaling pathway that is aberrantly required due to adaptation to a functionally relevant KRAS mutation (Scholl 2009)
  • selectively required for the survival and proliferation of mutant KRAS-dependent cancer cells across a wide range of tissue contexts (Scholl 2009)
  • promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through RPS6KB1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells (Scholl 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS