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FLASH GENE
Symbol STK31 contributors: mct - updated : 20-02-2019
HGNC name serine/threonine kinase 31
HGNC id 11407
Location 7p15.3      Physical location : 23.749.837 - 23.872.126
Synonym symbol(s) TDRD8, SGK396
EC.number 2.7.1.37/2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 122.38 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HYAL4 7q31.3 hyaluronoglucosaminidase 4 SBBI26 7p15.3 SBBI26 protein LOC392642 7 similar to Neuronal protein 3.1 (p311 protein) LOC392643 7 hypothetical gene supported by BC026177 TRA2A 7p15.3 transformer-2 alpha KPI2 7q22.1 transformer-2 alpha NUPL2 7p15 nucleoporin like 2 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC392644 7 hypothetical gene supported by BC022025; NM_003993 GPNMB 7p15 glycoprotein (transmembrane) nmb LOC90693 7p15.3 alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase-like MIST1 7q22.1 class II bHLH protein MIST1 DKFZP434B0335 7q22.1 DKFZP434B0335 protein C7orf30 7p15.3 chromosome 7 open reading frame 30 IMP-3 7p11 IGF-II mRNA-binding protein 3 LOC392981 7 similar to RIKEN cDNA 6332401O19 gene LOC340277 BRI3 7q22.1 brain protein I3 STK31 7p15.3 serine/threonine kinase 31 LOC55971 7q22.1 insulin receptor tyrosine kinase substrate LOC389473 7 similar to Neuronal protein 3.1 (p311 protein) MGC27348 7p15.3 similar to ribosomal protein S2; 40S ribosomal protein S2 TRA2A 7p15.3 transformer-2 alpha LOC346404 7p15.3 similar to ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) (HuHP68) LOC90693 7p15.3 alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase-like LOC340277 NPTX2 7q21.3-q22.1 neuronal pentraxin II STK31 7p15.3 serine/threonine kinase 31 LOC392982 7 similar to RIKEN cDNA 1500011L16 LOC392781 7 similar to 40S ribosomal protein S2 DKFZp761L1417 7q22.1 hypothetical protein DKFZp761L1417 NPY 7p15.1 neuropeptide Y TRRAP 7q21.3-q22.1 transformation/transcription domain-associated protein GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC392782 7 LOC392782 SMURF1 7q21.1-q31.1 LOC392782 POT1 7q31.33 protection of telomeres 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
24 splicing 3326 - 1019 - 2016 27044426
23 - 3257 - 996 - 2016 27044426
STK31
24 - 3602 - 996 - 2016 27044426
24 - 3570 - 996 - 2016 27044426
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
reproductivetestisgerminal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TUDOR domain,
  • coiled coil domain
  • serine/threonine protein kinase (STK) catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Stk31
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • co-localizes with pericentrin in the centrosomal region throughout all phases of the cell cycle; also localizes to the centromeres, central spindle, and midbody
  • basic FUNCTION
  • is able to control the differentiation state of colon cancer cells, which critically depends on its STK domain
  • STK31 may be redundant with other TDRD proteins in germ cell development
  • STK31 gene of which the expression has been proven to be regulated by the methylation status of its promoter, is one of the novel cancer/testis (CT) genes and plays important roles in cancers
  • STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be a novel cellular target gene for the HPV16 oncogeneE7
  • STK31 interacts with PDCD5, which maintains the stability of PDCD5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in patients with pancreatic carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum FBLN1 and STK31 are biomarkers of colorectal cancer, having ability to noninvasively differentiate colorectal cancer from benign polyps
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    might act as a potential therapeutic target in human somatic cancers
    ANIMAL & CELL MODELS
  • mouse Stk31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization