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FLASH GENE
Symbol STK3 contributors: mct - updated : 16-12-2014
HGNC name serine/threonine kinase 3
HGNC id 11406
Location 8q22.2      Physical location : 99.466.861 - 99.837.909
Synonym name
  • serine/threonine kinase 3 (STE20 homolog, yeast)
  • mammalian steril 20-like 2
  • kinase responsive to stress 1
  • STE20-like kinase MST2
  • serine/threonine-protein kinase Krs-1
  • Synonym symbol(s) DBK, KRS1, MST2, FLJ90748
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 487.94 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1 FLJ13955 8q22.2 hypothetical protein FLJ13955 KCNS2 8q23.3-q24.11 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 STK3 8q22.2 serine/threonine kinase 3 (STE20 homolog, yeast) MRP63P7 8q22.2 mitochondrial ribosomal protein 63 pseudogene 7 OSR2 8q22.2 odd-skipped-related 2A protein COH1 8q22.2 Cohen syndrome 1 COX6C 8q22-q23 cytochrome c oxidase subunit VIc DKFZP434I092 8q22.3 DKFZP434I092 protein LOC286151 8q22.3 similar to RIKEN cDNA 4930533G20 POLR2K 8q22 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa SPAG1 8q22 sperm associated antigen 1 RNF19 8q22 ring finger protein 19 LOC157567 8q22.3 hypothetical protein LOC157567 MGC39715 8q22.3 hypothetical protein MGC39715 PABPC1 8q22.2-q23 poly(A) binding protein, cytoplasmic 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3171 - 519 - 1995 8566796
    9 - 2485 - 380 - 1995 8566796
    11 - 2828 - 491 - 2009 19525978
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Nervousbrain    
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal catalytic domain
  • SARAH domains acting as a platform to mediate homodimerization and hetero-interaction with a range of adaptors including RASSFs and Salvador, which also possess SARAH domains (hetero-interaction with RASSF5 are required for full activation of STK3 and therefore apoptotic functions in T cells)
  • conserved C-terminal coiled-coil domains
  • HOMOLOGY
    interspecies homolog to yeast Ste20
    homolog to murine Stk3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • serine threonine kinase
  • playing a role in the response to environmental stress
  • phosphorylates and activates both LATS1 and LATS2
  • with STK4, are activated in mitosis and catalyze the mitotic phosphorylation of MOBKL1A/MOBKL1B
  • serves as a hub to integrate biological outputs of the RAF1 and AKT pathways
  • STK3-, FRY-, and MOB2-mediated activation of STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells
  • STK3, STK4 control Rho GTPase activation and the migratory responses of single-positive (SP) thymocytes
  • STK3/STK4 are required for proper cardiac lineage cell development and teratoma formation
  • STK3, STK4 are key players in mammalian Hippo pathway
  • STK3/STK4 regulate potentially placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and STK3/STK4 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forming an active complex with RASSF2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SAV1 (SAV1 can bind to, and be phosphorylated by STK3, and the stabilizing effect of STK3 on SAV1 requires its interaction with SAV1 but is probably not due to phosphorylation of SAV1 by STK3)
  • binding partner of RASSF2 (STK3 and RASSF2 form an active complex, in which RASSF2 is maintained in a phosphorylated state and protects STK3 from degradation and turnover)
  • STK3 and the scaffold protein Salvador (SAV1), directly interact with NEK2 and regulate its ability to localize to centrosomes, and phosphorylate CEP250 and rootletin
  • RASSF1 interacts with and activates STK3/STK4 kinases by preventing their dephosphorylation
  • MST2-mediated phosphorylation of four residues within SAV1 may be important in the induction of cell death by the MST pathway
  • STK3/STK4 timulated the binding of SAV1 to PPARG, a transcription factor that plays a key role in adipogenesis
  • ABL1 is a novel upstream activator of STK3 suggesting that the conserved ABL1-MST signaling cascade plays an important role in oxidative stress-induced neuronal cell death
  • ADRBK1 plays a central role in mitogen-promoted centrosome separation most likely via its ability to phosphorylate STK3
  • RASSF5 can act as an inhibitor or a potential positive regulator of STK3, depending on whether it binds to STK3 before or after activation-loop phosphorylation
  • cell & other
    REGULATION
    activated by cell stress
    RASSF1 (activates STK3 and STK4 by promoting their autophosphorylation and phosphorylation of the downstream LATS1 kinase)
    inhibited by RASSF6 (RASSF6 inhibited MST2 activity to antagonize Hippo signaling)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS