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FLASH GENE
Symbol STK19 contributors: npt/ - updated : 02-10-2007
HGNC name serine/threonine kinase 19
HGNC id 11398
Location 6p21.3      Physical location : 3.224.534 - 31.981.960
Synonym name
  • DNA segment,single copy,probe G11,HTF associated G11 (see HTFAG@)
  • MHC class III HLA-RP1
  • nuclear serine/threonine protein kinase
  • Synonym symbol(s) HTFAG11, D6S60E, G11, RP1, D6S60, HLA-RP1, D6S974E, MGC117388
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text head to head with DOM3Z
    STRUCTURE 9.58 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    motif repetitive sequence   ALU   other
    text structure
  • a SVA element (SINE/VNTR/Alu) in intron 4
  • 8 alu elements in intron 4
  • common 5' regulatory region of each gene with unmethylated CpG sequence
  • MAPPING cloned Y linked   status confirmed
    Map see HTFAG@ ,TNXB
    Physical map
    BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2 CLIC1 6p21.3 chloride intracellular channel 1 MSH5 6p21.3 mutS homolog 5 (E. coli) C6orf27 6p21.31 chromosome 6 open reading frame 27 VARS2 6p21.3 valyl-tRNA synthetase 2 LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B C6orf48 6p21.3 chromosome 6 open reading frame 48 NEU1 6p21.3 sialidase 1 (lysosomal sialidase) C6orf29 6p21.3 chromosome 6 open reading frame 29 BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2 BF 6p21.3 B-factor, properdin RDBP 6p21.33 RD RNA binding protein SKIV2L 6p21.3 superkiller viralicidic activity 2-like (S. cerevisiae) DOM3Z 6p21.3 dom-3 homolog Z (C. elegans) STK19 6p21.3 serine/threonine kinase 19 C4B 6p21.3 complement component 4B CYP21A2 6p21.3 cytochrome P450, family 21, subfamily A, polypeptide 2 TNXB 6p21.3 tenascin XB CREBL1 6p21.3 cAMP responsive element binding protein-like 1 FKBPL 6p21.3 FK506 binding protein like C6orf31 6p21.1 chromosome 6 open reading frame 31 PPT2 6p21.3 palmitoyl-protein thioesterase 2 EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    text four isoforms by alternative splicing
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1620 40.5 364 - Shen, 94
    - splicing 1632 40.9 368 - Shen
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelial    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Digestivehepatocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    putative nuclear localization motif,multiple potential phosphorylation,two amidation and nine potential N-myristoylation sites
    HOMOLOGY
    interspecies homolog to murine Stk19
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION serine/threonine kinase
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    manganese Mn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS