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FLASH GENE
Symbol STK17B contributors: mct - updated : 25-09-2010
HGNC name serine/threonine kinase 17b
HGNC id 11396
Location 2q32.3      Physical location : 196.998.307 - 197.036.336
Synonym name
  • serine/threonine kinase 17b (apoptosis-inducing)
  • death-associated protein kinase-related 2
  • DAP-related apoptotic kinase-2
  • Synonym symbol(s) DRAK2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 38.03 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391469 2 similar to hypothetical protein FLJ10634 LOC389067 2 LOC389067 LOC343981 2q33.1 similar to Glutamine synthetase (Glutamate--ammonia ligase) LOC391470 2 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) SLC39A10 2q33.1 solute carrier family 39 (zinc transporter), member 10 DNAH7 2q33-1 dynein, axonemal, heavy polypeptide 7 STK17B 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) NEDL2 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) FLJ39660 2q33.1 hypothetical protein FLJ39660 LOC200624 2q33.1 hypothetical LOC200624 DKFZp434P055 2q33.1 hypothetical protein DKFZp434P055 GTF3C3 2q33.1 general transcription factor IIIC, polypeptide 3, 102kDa LOC389068 2 similar to ISPD3024 FLJ12377 LOC91526 2q33.1 hypothetical protein DKFZp434D2328 LOC391471 2 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 SF3B1 2p23.3-q34 splicing factor 3b, subunit 1, 155kDa FLJ13448 2q33.1 hypothetical protein FLJ13448 HSPD1 2q33.1 heat shock 60kDa protein 1 (chaperonin) HSPE1 2q33.1 heat shock 10kDa protein 1 (chaperonin 10) PREI3 2q33.1 preimplantation protein 3 C2orf11 2q33.1 chromosome 2 open reading frame 11 LOC92935 2q33.1 hypothetical protein BC009115 BOLL 2q33.1 bol, boule-like (Drosophila) PLCL1 2q33 phospholipase C-like 1 SATB2 2q32-q33 SATB family member 2 FLJ32063 2q33.1 hypothetical protein FLJ32063
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5324 42.3 372 - PMID: 11481038
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    Nervousbrain   lowly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal kinase domain
  • putative nuclear-localization signal (NLS) sequence
  • a regulatory domain of kinase activity in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • serine/threonine kinase family
  • death-associated protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text phosphorylation of Ser350 plays an essential role in regulating translocation to the nucleus from the cytoplasm, possibly by affecting the activity of the nuclear localization signal
    basic FUNCTION
  • phosphorylation of the myosine light chain (MLC)
  • autophosphorylation
  • its kinase activity is regulated in a calcium-dependent manner and Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase
  • role in regulating the germinal center reaction and the response to thymus-dependent antigens, perhaps through increased survival of T cells and enhanced B-cell positive selection
  • serine-threonine kinase implicated in the regulation of apoptosis and negatively regulated by PTGS2, suggesting a novel mechanism for the effect of PTGS2 on cancer cell survival
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text induction of apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by CHP for both autophosphorylation and phosphorylation of exogenous substrate (myosin light chain)in a calcium-dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in a panel of human colorectal tumours compared to normal mucosa
    constitutional     --over  
    results in increased beta-cell apoptosis after free fatty acid stimulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • drak2-deficient mice are enigmatically resistant to induced autoimmunity in the model experimental autoimmune encephalomyelitis