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FLASH GENE
Symbol STK17A contributors: npt/ - updated : 17-05-2006
HGNC name serine/threonine kinase 17a
HGNC id 11395
Location 7p14-p12      Physical location : 43.622.691 - 43.666.977
Synonym name
  • death-associated protein kinase-related 1
  • serine/threonine kinase 17a (apoptosis-inducing)
  • Synonym symbol(s) DRAK1, SI7A
    EC.number 2.7.1.37, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 44.29 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0738 7q35 mitochondrial ribosomal protein S24 STK17A 7p14-p12 serine/threonine kinase 17a (apoptosis-inducing) LOC393043 7 similar to Olfactory receptor 2F2 (Olfactory receptor 7-1) (OR7-1) FLJ10803 7p13 hypothetical protein FLJ10803 OR2F1 7q35 olfactory receptor, family 2, subfamily F, member 1 LOC393044 7 similar to olfactory receptor MOR257-3 KIAA0322 7p22 similar to olfactory receptor MOR257-3 LOC393045 7 similar to Olfactory receptor 6B1 (Olfactory receptor 7-3) (OR7-3) LOC393046 7 similar to olfactory receptor MOR261-13 LOC393047 7 similar to olfactory receptor MOR261-1 BLVRA 7p14-cen biliverdin reductase A LOC393048 7 similar to Olfactory receptor 2A12 LOC393049 7 similar to seven transmembrane helix receptor LOC393050 7 similar to seven transmembrane helix receptor LOC393051 7 similar to seven transmembrane helix receptor LOC393052 7 similar to seven transmembrane helix receptor LOC393053 7 similar to seven transmembrane helix receptor MRPS24 7p14 mitochondrial ribosomal protein S24 LOC340310 7q35 similar to hypothetical protein MGC41943 FLJ43692 7q35 FLJ43692 protein URG4 7p13 up-regulated gene 4 LOC393054 7 similar to Olfactory receptor 2A1 LOC51619 7p13 ubiquitin-conjugating enzyme HBUCE1 LOC393055 7 hypothetical gene supported by BC016940 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 STK17A 7p14-p12 serine/threonine kinase 17a (apoptosis-inducing) LOC392664 7 similar to RAS p21 protein activator 4; GTPase activating protein-like; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator LOC393056 7 similar to Olfactory receptor 2A1 FLJ10803 7p13 hypothetical protein FLJ10803 WBSCR19 7q11.23 Williams Beuren syndrome chromosome region 19 LOC393057 7 hypothetical gene supported by BC016940 ARHGEF5 7q33-q35 Rho guanine nucleotide exchange factor (GEF) 5 LOC392893 7 similar to RasGAP-activating-like protein 2 (Calcium-promoted Ras inactivator) HIP-55 7p13 src homology 3 domain-containing protein HIP-55 LOC393058 7 similar to OG-2 homeodomain protein-like; similar to U65067 (PID:g1575526) PGAM2 7p13-p12 phosphoglycerate mutase 2 (muscle) POLM 7p13 polymerase (DNA directed), mu LOC393059 7 similar to peptidyl-Pro cis trans isomerase AEBP1 7p15.1 AE binding protein 1 TPK1 7q34 thiamin pyrophosphokinase 1 POLD2 7p15.1 polymerase (DNA directed), delta 2, regulatory subunit 50kDa BLVRA 7p14-cen biliverdin reductase A MYL7 7p21-p11.2 myosin, light polypeptide 7, regulatory GCK 7p14-p13 glucokinase (hexokinase 4, maturity onset diabetes of the young 2) YKT6 7p15.1 SNARE protein Ykt6 CAMK2B 7p13 calcium/calmodulin-dependent protein kinase (CaM kinase) II beta MRPS24 7p14 mitochondrial ribosomal protein S24
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3949 46.5 414 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   lowly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivemale systemprostate  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal kinase domain
  • a regulatory domain of kinase activity in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • DAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylates the myosin light chain (mlc)
  • autophosphorylation
  • involved in osteoclast apoptosis
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text induction of apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS