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FLASH GENE
Symbol STK10 contributors: mct - updated : 30-03-2020
HGNC name serine/threonine kinase 10
HGNC id 11388
Location 5q35.1      Physical location : 171.469.073 - 171.615.346
Synonym name lymphocyte oriented kinase
Synonym symbol(s) LOK, PRO2729
EC.number 2.7.11.1
DNA
TYPE like-sequence
STRUCTURE 146.27 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 6039 112 968 - 1999 10199912
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • kinase domain at the N terminus, N-terminal domain can then access a site 40 AAs distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue
  • the coiled-coil region at the C terminus
  • HOMOLOGY
    interspecies homolog to murine Stk10
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • localize to the membrane of peripheral blood lymphocytes
  • STK10 is localized to microvilli via the C-terminal domain
  • basic FUNCTION
  • acting on substrates such as myelin basic protein and histone 2A on serine and threonine residues
  • polo-like kinase kinase that cooperates with SLK to regulate PLK1 function in human cells
  • playing a role in ERM ((ezrin-radixin-moesin) phosphorylation, and major ERM kinase in lymphocytes
  • STK10 functions as a tumor suppressor gene, and dysfunction of STK10 activity either through polymorphism or somatic mutations may confer anti-apoptotic effects contributing to carcinogenesis
  • is synthesized mainly in lymphocytes
  • in mitotic cells, STK10-activated EZR is required to prevent excessive accumulation of MISP at the cell cortex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with MAP3K1 (MAP3K1 and STK10 may have opposing roles in regulating the CD28RE/AP1 element of IL2)
  • in epithelial cells, ezrin is mainly phosphorylated at T567 by STK10
  • STK10 and SLK are functionally the major relevant kinases involved in the steady-state phosphorylation of EZR in Jeg-3 cells
  • involved in lymphocyte migration and polarization and can phosphorylate EZR, RDX, and MSN (the ERM proteins)
  • cleavage of STK10 during apoptosis abolishes its kinase activity, causing a decrease in ERM phosphorylation, crucial to the role of the ERM proteins in linking the plasma membrane to actin filaments
  • EZR through STK10 is only phosphorylated at the plasma membrane, and with high specificity by the apically localized kinase STK10
  • MISP directly interacts with EZR and STK10-activated EZR ensures appropriate cortical MISP levels in mitosis by competing with MISP for actin-binding sites at the cell cortex
  • cell & other
    REGULATION
    Other attenuating the activation of CD28 by MEKK1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in Peripheral T-cell lymphoma (PTCL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS