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FLASH GENE
Symbol STK10 contributors: mct - updated : 22 -09-200
HGNC name serine/threonine kinase 10
HGNC id 11388
Location 5q35.1      Physical location : 171.469.073 - 171.615.346
Synonym name lymphocyte oriented kinase
Synonym symbol(s) LOK, PRO2729
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 146.27 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
FOXI1 5q34 forkhead box I1 LOC345430 5q35.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC133874 5q35.1 hypothetical gene LOC133874 LCP2 5q34 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) KCNMB1 5q34 potassium large conductance calcium-activated channel, subfamily M, beta member 1 KCNIP1 5q35.2 Kv channel interacting protein 1 LOC389343 5 LOC389343 GABRP 5q33-q34 gamma-aminobutyric acid (GABA) A receptor, pi RANBP17 5q31 RAN binding protein 17 USP12P1 5q33-q34 ubiquitin specific protease 12 pseudogene 1 TLX3 5q35.1 T-cell leukemia, homeobox 3 LOC391847 5 similar to hypothetical protein LOC391848 5 similar to 60S ribosomal protein L10 (QM protein homolog) NPM1 5q35 nucleophosmin (nucleolar phosphoprotein B23, numatrin) FGF18 5q34 fibroblast growth factor 18 FBXW1B 5q35.1 F-box and WD-40 domain protein 1B STK10 5q35.1 serine/threonine kinase 10 LOC285588 5q35.2 similar to RIKEN cDNA 1700007I06 DC-UbP 5q35.2 dendritic cell-derived ubiquitin-like protein KIAA1295 5q35.2 KIAA1295 protein LOC391849 5 similar to neuralized homolog LOC133539 5q35.2 similar to RIKEN cDNA 1810009O10 DUSP1 5q34 dual specificity phosphatase 1 KIAA1181 5q35.2 KIAA1181 protein LOC389344 5 LOC389344 RPL26L1 5q35.2 ribosomal protein L26-like 1 LOC285591 5q35.2 inorganic pyrophosphatase pseudogene ATP6V0E 5q35.3 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e LOC153222 5q35.2 adult retina protein BNIP1 5q33-q34 BCL2/adenovirus E1B 19kDa interacting protein 1 LOC391850 5 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) NKX2-5 5q34-q35.3 NK2 transcription factor related, locus 5 (Drosophila) STC2 5p14.2-q15 stanniocalcin 2 LOC389345 5 LOC389345 LOC91272 5q35.2 hypothetical protein BC007436 CPEB4 5q21 cytoplasmic polyadenylation element binding protein 4 HMP19 5q35.2 HMP19 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 6039 112 968 - 1999 10199912
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • kinase domain at the N terminus
  • the coiled-coil region at the C terminus
  • HOMOLOGY
    interspecies homolog to murine Stk10
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting on substrates such as myelin basic protein and histone 2A on serine and threonine residues
  • polo-like kinase kinase that cooperates with SLK to regulate PLK1 function in human cells
  • playing a role in ERM ((ezrin-radixin-moesin) phosphorylation, and major ERM kinase in lymphocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with MAP3K1 (MAP3K1 and STK10 may have opposing roles in regulating the CD28RE/AP1 element of IL2)
  • cell & other
    REGULATION
    Other attenuating the activation of CD28 by MEKK1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS