SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,granule
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| text
| single-pass type 1 membrane protein |
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sensors of endoplasmic reticulum (ER) luminal Ca2+ changes and rapidly translocate into near plasma membrane (PM) junctions to activate Ca2+ entry  |
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expressed in the lysosome-related organelles and dense granules in human platelets |
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exists in at least three distinct functional forms that reside in the ER and in the cytosol |
| basic FUNCTION
| inhibiting STIM1-mediated Ca(2+) influx |
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involved in negative regulation of calcium ion transport via store-operated calcium channel |
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having two distinct modes of activating Ca2+ release-activated Ca2+ channels |
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transmembrane endoplasmic reticulum Ca2+ sensors, coupling directly to activate plasma membrane ORAI1 Ca2+ entry channels |
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play a relevant role in intracellular Ca2+ homeostasis as a feedback regulator that stabilizes resting cytosolic and ER Ca2+ concentrations |
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both STIM1 and STIM2 have a capacity to bind to a chaperone, calnexin as well as two protein-transporters, exportin1 and transportin1 |
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potential functional role for STIM1 and STIM2 located in the acidic Ca2+ stores |
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expression of STIM1 and STIM2 in acidic organelles that function as agonist-sensitive Ca2+ stores |
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unlike STIM1, STIM2 can regulate ORAI1 in a store-dependent and store-independent manner |
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STIM2 signal peptide functions to augment NF-KB-mediated gene transcription after its release as a & |
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8764;91-aa SPF into the cytosol |
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potential role for STIM1, STIM2 proteins and T-cell function in the pathogenesis of Sjögren syndrome |
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STIM1 and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoinositides at the PM via their cytosolic lysine (K)-rich domains, and activate Ca2+ channels |
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STIM1 and STIM2 are endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane ORAI1 Ca(2+) channels |
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STIM1, STIM2, and ORAI1 regulate store-operated calcium entry and purinergic activation of microglia |
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is a central organizer of excitatory synapses, and influences the formation of dendritic spines and shapes basal synaptic transmission in excitatory neurons |
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unique mechanism of synaptic plasticity driven by dynamic assembly of a STIM2 signaling complex at ER-plasma membrane (PM) contact sites |
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protects hippocampal mushroom spines from amyloid synaptotoxicity |
