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FLASH GENE
Symbol STC1 contributors: mct/npt/pgu - updated : 06-08-2014
HGNC name stanniocalcin 1
HGNC id 11373
Location 8p21.2      Physical location : 23.699.433 - 23.712.320
Synonym symbol(s) STC, STC-1
DNA
TYPE functioning gene
STRUCTURE 12.89 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • HIF-1A binding motif in human STC1 gene promoter
  • MAPPING cloned Y linked N status confirmed
    Map pter - D8S505 - STC1 - D8S298 - D8S131 - D8S339 - cen
    Physical map
    FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776 RHOBTB2 8p21.2 Rho-related BTB domain containing 2 TNFRSF10B 8p21 tumor necrosis factor receptor superfamily, member 10b LOC389640 8 LOC389640 TNFRSF10C 8p21 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain TNFRSF10D 8p21 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain TNFRSF10A 8p21 tumor necrosis factor receptor superfamily, member 10a LOC389641 8 hypothetical gene supported by AK124295 MGC29816 8p21.2 hypothetical protein MGC29816 LOC203069 8p21.2 hypothetical protein LOC203069 LOXL2 8p21.3-p21.2 lysyl oxidase-like 2 LYSAL1 8p22-p21.3 lysosomal apyrase-like 1 MSCP 8p21.2 mitochondrial solute carrier protein PRO1496 8p21.2 hypothetical protein PRO1496 LOC389642 8 LOC389642 NKX3-1 8p21 NK3 transcription factor related, locus 1 (Drosophila) LOC137814 8p21.2 similar to homeobox protein NKX2-6 STC1 8p21-p11.2 stanniocalcin 1 ADAM28 8p21.3-p12 a disintegrin and metalloproteinase domain 28 ADAMDEC1 8p21.1 ADAM-like, decysin 1 ADAM7 8p21.2 a disintegrin and metalloproteinase domain 7 NEF3 8p22-p21 neurofilament 3 (150kDa medium) NEFL 8p21 neurofilament, light polypeptide 68kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3897 - 247 - 2007 17032941
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinethyroid    
    Reproductivefemale systemovary  predominantly Homo sapiens
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidneynephron  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal, pregnancy
    Text highly in pregnancy and lactation
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a motif containing a cysteine–serine dipeptide, which binds both ferrous (Fe2+) and ferric (Fe3+) heme, and with Cys114 being indispensible for binding
  • conjugated PhosphoP , Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Stc
    intraspecies paralog to STC2
    Homologene
    FAMILY
  • stanniocalcin family
  • CATEGORY regulatory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative regulator of mineral phosphate homeostasis, likely by stimulation of phosphate uptake by the renal tubule
  • role in reproduction
  • could effectively prevent cytosolic Ca(2+) overload and protect cardiomyocytes from pathophysiological conditions such as in the failing heart
  • pro-apoptotic factor
  • regulates endothelial gene expression and modulates transendothelial migration of leukocytes, playing a critical role in transendothelial migration of inflammatory cells and being involved in the regulation of numerous aspects of endothelial function
  • STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress
  • key regulator of superoxide generation in macrophages, suggesting that STC1 may profoundly affect the immune/inflammatory response
  • modulator or purinergic receptor signaling
  • promotes the expression of VEGF, and VEGF subsequently enhances tumor angiogenesis which in turn promotes the gastric tumor growth
  • endocrine regulator of gill Ca(2+) uptake during hypercalcemia
  • STC1, STC2 are known to be involved in tumor progression and metastasis
  • STC1 and STC2 play positive roles in angiogenic sprouting
  • is a proteinase inhibitor, suggesting a previously unrecognized function of STC1 in the IGF system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism metal
    signaling
    mineral
    a component
  • 56 kDa homodimeric glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • known regulator of angiogenesis, and target gene of WNT2 signaling in HUVEC down-regulated by WNT2 treatment
  • STC1 Cys114 is essential for hemin binding (heme bound to STC1 may have an impact on the redox balance of the cell, which becomes more evident under oxidative stress)
  • presence of native complexes between PAPPA and STC1, STC2 in the human ovary, indicating STC-mediated PAPPA proteolytic inhibition
  • cell & other
    REGULATION
    activated by histone hyper-acetylation and the recruitment of activated NFkappaB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in primary breast tumor (with BRCA1)
    tumoral     --over  
    in ovarian cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS