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FLASH GENE
Symbol STAU2 contributors: mct/npt - updated : 08-12-2014
HGNC name staufen, RNA binding protein, homolog 2 (Drosophila)
HGNC id 11371
Location 8q21.1      Physical location : 74.332.605 - 74.659.943
Synonym name staufen homolog 2
Synonym symbol(s) 39K2, 39K3, DKFZp781K0371, MGC119606
DNA
TYPE functioning gene
STRUCTURE 327.34 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3065 - 570 - 2012 22940085
10 - 2459 - 398 - 2012 22940085
14 - 2888 - 504 - 2012 22940085
14 - 2934 - 538 - 2012 22940085
12 - 4161 53 479 - 2012 22940085
10 - 3982 - 473 - 2012 22940085
11 - 4225 - 479 - 2012 22940085
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
 brain   specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three double-stranded RNA-binding (ds RBD) domains, (the third double-stranded RNA-binding domain (RBD3)is essential for RNA interaction)
  • HOMOLOGY
    interspecies homolog to Drosophila Staufen,2
    Homologene
    FAMILY
  • double-stranded RNA (dsRNA)-binding proteins family
  • CATEGORY regulatory , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    text nuclear import is dependent on a nuclear localization signal in close proximity to the RBD3, the nuclear export is not dependent on CRM1 but rather on XPO5
    basic FUNCTION
  • involved in RNA localization in polarized neurons
  • involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles
  • important role in the formation and maintenance of dendritic spines of hippocampal neurons
  • dendritic mRNA transport is mediated potentially via the STAU2 and kinesin motor proteins and might be modulated by the neuronal activity and mitogen-activated protein kinase pathway
  • could be involved in double-stranded RNA binding events
  • transport dendritic mRNAs along microtubules
  • potential role for STAU2 in the generation and regulation of MAP1B mRNA containing granules that are required for GRM-dependent long-term depression
  • implicated in mRNA transport and dendritic spine morphogenesis
  • recruitment of STAU2 alone or in combination with UPF1 differentially affects the fate of mRNAs
  • double-stranded mRNA binding protein known to regulate dendrite formation as well as cell survival and migration
  • translation control of specific STAU2-associated transcripts may be a key regulator of tissue size
  • regulates eye size during development and all STAU2 isoforms expressed in the neuropethelial tissue share this important ability
  • functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity
  • implicated in both dendritic RNA localization and synaptic plasticity in mammalian neurons
  • is likely an anti-apoptotic protein that could be involved in DNA replication and/or maintenance of genome integrity and its expression is regulated by E2F1 via the ATR signaling pathway
  • double-stranded RNA-binding protein involved in cell fate decision by regulating mRNA transport, mRNA stability, translation, and ribonucleoprotein assembly
  • is likely required for spindle formation and timely meiotic progression in oocytes
  • RNA-binding protein involved in the post-transcriptional regulation of gene expression
  • critical contribution of STAU2 to various forms of synaptic plasticity including spatial working memory and cognitive management of new environmental information
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of RNPs that travel along microtubules from the soma to distant dendritic sites
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with XPO5, through the RBD3 in an RNA-dependent manner
  • interaction of STAU2 with the Y14-MAGOHB heterodimer seems to represent a highly conserved complex as the same proteins are involved in the STAU2-mediated localization of Oskar mRNA in Drosophila oocytes
  • ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2
  • MAPK pathway could modulate dendritic mRNA transport through its interaction with STAU2
  • PABPC1L and YBX1 associate with STAU2-containing mRNPs through RNAs
  • RUFY3 binding with STAU2
  • involved in the regulation of two important genes that regulate eye size, SOX2, HES1
  • double-stranded RNA-binding protein that interacts directly with UPF1 to reduce the half-life of STAU1-mediated mRNA decay targets that form an STAU1-binding site by either intramolecular or intermolecular base-pairing
  • cell & other
    REGULATION
    Phosphorylated by CDK1 (STAU2 isoforms are phosphorylated during mitosis and the phosphorylation process involves CDK1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS