SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,cytoplasm,cytoskeleton,microfilament
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| intracellular,nucleus,nucleolus
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text
| mainly localized to the rough endoplasmic reticulum, and in the nucleus/nucleolus, suggesting nucleocytoplasmic shuttling or other functions |
basic FUNCTION
| involved in mRNA transport and localization |
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targeting of RNA to its site of translation |
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playing a putative role in the regulation of translation |
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involved in RNA localization in polarized neurons |
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influences the expression of a wide variety of physiologic transcripts and metabolic pathways |
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crucial for synapse development but not critical for normal behavioral function |
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implicated in dendritic RNA localization in neurons, translational control, and mRNA decay |
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RNA-binding protein involved in transport, localization, decay, and translational control of mRNA |
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important for processing and/or transporting in dendrites mRNAs that are critical in regulation of synaptic strength and maintenance of functional connectivity changes underlying hippocampus-dependent learning and memory |
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thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1) |
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recruited to stress granules upon induction of endoplasmic reticulum or oxidative stress as well in stress granules induced by translation initiation blockers |
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involved in recovery from stress by stabilizing polysomes, thus helping stress granule dissolution |
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relevant role in the influenza A virus replication |
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critical protein regulating the anterior to posterior distribution of some mRNAs, in oocyte development |
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STAU1 self-associates in mRNPs via its multiple functional domains that can select mRNAs to be transported and establish protein-protein interaction |
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required for protein synthesis-dependent long-term potentiation (L-LTP) in hippocampal pyramidal cells |
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role of STAU1-dependent mRNA regulation in physiological and morphological changes underlying long-term synaptic plasticity in pyramidal cells |
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DVL2 has an inhibitory role in myogenesis and STAU1 coordinates myogenesis through the regulation of DVL2 mRNA |
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potential role for STAU1 in viral replication |
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double-stranded RNA binding protein involved in diverse gene expression pathways |
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biological role for STAU1-mediated mRNA decay in adipogenesis |
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novel function for STAU1 in splicing regulation |
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TINCR together with STAU1 is required for epidermal differentiation |
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role for TINCR as an epithelial-specific guide for targeting the STAU1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue |
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regulates translation of transcription-regulatory proteins |
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STAU1 identifies a wide spectrum of cellular target mRNAs to control their localization, expression and fate |
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RNA-binding protein involved in the post-transcriptional regulation of gene expression |
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participates potentially in a mechanism of post-transcriptional regulation of gene expression that is linked to cell cycle progression in cancer cells |
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highly expressed during early stages of differentiation/development and it can impair differentiation by regulating MYC, thereby highlighting the multifunctional role of STAU1 in skeletal muscle cells |
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splicing regulator and may likely act as a disease modifier in DM1 (Myotonic dystrophy type 1) |