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Symbol STAU1 contributors: mct/npt - updated : 23-08-2016
HGNC name staufen, RNA binding protein, homolog 1 (Drosophila)
HGNC id 11370
Location 20q13.13      Physical location : 47.729.877 - 47.804.904
Synonym name Drosophila Staufen homolog 1
Synonym symbol(s) PPP1R150, STAU, FLJ25010
TYPE functioning gene
STRUCTURE 105.96 kb     12 Exon(s)
text structure
  • no TATA, CAAT boxes
  • an extremely G+C rich region in 5'utr
  • MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3688 63 577 - 2004 15303970
  • variant T3, STAU1-63
  • STAU1-63 variant that is 81 AAs longer at its N-terminal region compared to the 55 kDa (STAU1-55)
  • 12 splicing 3340 55 496 - 2004 15303970
  • STAU1-55, variant T1
  • 11 splicing 3399 - 496 - 2004 15303970
    variant T2
    14 - 3522 - 496 - 2004 15303970
    variant T4
    14 - 3540 - 502 highly expressed in heart, liver, kidney and pancreas 2004 15303970
    variant T5
    15 - 3625 - 577 - 2004 15303970
    variant T7
    13 - 3539 - 577 - 2004 15303970
    variant T11
    15 - 3837 - 577 - 2004 15303970
    variant T10
    16 - 3817 - 536 - 2004 15303970
    variant T12
    12 - 3368 - 502 - 2004 15303970
    variant T8
    13 - 3443 - 502 - 2004 15303970
    variant T6
    13 - 3657 - 583 - 2004 15303970
    variant T13
    14 - 3732 - 583 - 2004 15303970
    variant T14
    15 - 3712 - 542 - 2004 15303970
    variant T9
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
     thymus   highly
    Reproductivemale systemprostate   
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • four double-stranded RNA-binding domain (RBD1-4)
  • a nuclear localization signal
    interspecies homolog to Drosophila Staufen
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
  • mainly localized to the rough endoplasmic reticulum, and in the nucleus/nucleolus, suggesting nucleocytoplasmic shuttling or other functions
  • basic FUNCTION
  • involved in mRNA transport and localization
  • targeting of RNA to its site of translation
  • playing a putative role in the regulation of translation
  • involved in RNA localization in polarized neurons
  • influences the expression of a wide variety of physiologic transcripts and metabolic pathways
  • crucial for synapse development but not critical for normal behavioral function
  • implicated in dendritic RNA localization in neurons, translational control, and mRNA decay
  • RNA-binding protein involved in transport, localization, decay, and translational control of mRNA
  • important for processing and/or transporting in dendrites mRNAs that are critical in regulation of synaptic strength and maintenance of functional connectivity changes underlying hippocampus-dependent learning and memory
  • thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1)
  • recruited to stress granules upon induction of endoplasmic reticulum or oxidative stress as well in stress granules induced by translation initiation blockers
  • involved in recovery from stress by stabilizing polysomes, thus helping stress granule dissolution
  • relevant role in the influenza A virus replication
  • critical protein regulating the anterior to posterior distribution of some mRNAs, in oocyte development
  • STAU1 self-associates in mRNPs via its multiple functional domains that can select mRNAs to be transported and establish protein-protein interaction
  • required for protein synthesis-dependent long-term potentiation (L-LTP) in hippocampal pyramidal cells
  • role of STAU1-dependent mRNA regulation in physiological and morphological changes underlying long-term synaptic plasticity in pyramidal cells
  • DVL2 has an inhibitory role in myogenesis and STAU1 coordinates myogenesis through the regulation of DVL2 mRNA
  • potential role for STAU1 in viral replication
  • double-stranded RNA binding protein involved in diverse gene expression pathways
  • biological role for STAU1-mediated mRNA decay in adipogenesis
  • novel function for STAU1 in splicing regulation
  • TINCR together with STAU1 is required for epidermal differentiation
  • role for TINCR as an epithelial-specific guide for targeting the STAU1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue
  • regulates translation of transcription-regulatory proteins
  • STAU1 identifies a wide spectrum of cellular target mRNAs to control their localization, expression and fate
  • RNA-binding protein involved in the post-transcriptional regulation of gene expression
  • participates potentially in a mechanism of post-transcriptional regulation of gene expression that is linked to cell cycle progression in cancer cells
  • highly expressed during early stages of differentiation/development and it can impair differentiation by regulating MYC, thereby highlighting the multifunctional role of STAU1 in skeletal muscle cells
  • splicing regulator and may likely act as a disease modifier in DM1 (Myotonic dystrophy type 1)
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    a component
  • components of RNPs that travel along microtubules from the soma to distant dendritic sites
  • TARDBP is physically associated with FMR1 and Staufen (STAU1) to form a functional complex, and depletion of TARDBP/FMR1/STAU1 sensitizes cells to apoptosis and DNA damages
    RNA binding to double stranded RNA
    small molecule
  • linked to nucleocytoplasmic RNA-binding protein nucleolin in an RNA-dependent manner
  • binds to a complex structure within the ARF1 3'-UTR
  • binds to 3prime untranslated region (UTR) of DVL2 mRNA, and after induction of myogenic differentiation, this association was decreased
  • TARDBP is physically associated with fragile X mental retardation protein (FMR1) and Staufen (STAU1) to form a functional complex
  • TARDBP/FMR1/STAU1 specifically binds to the 3prime-UTR of SIRT1 mRNA (
  • STAU2 interacts directly with UPF1 to reduce the half-life of STAU1-mediated mRNA decay targets that form an STAU1-binding site by either intramolecular or intermolecular base-pairing
  • TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of gastric cancer (GC)cells
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    rescues alternative splicing of two key pre-mRNAs known to be aberrantly spliced in DM1 (Myotonic dystrophy 1), suggesting its increased expression represents an adaptive response to the pathology
    Variant & Polymorphism
    Candidate gene
    Therapy target
    may positively modulate the complex Myotonic dystrophy 1 phenotype, thereby revealing its potential as a therapeutic target