SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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text
| present in plasma membrane rafts, translocated to nucleus after activation |
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prior to phosphorylation, primarily resident in the cytoplasm, however, we found that it dynamically shuttles between nuclear and cytoplasmic compartments |
basic FUNCTION
| transcription activator in response to cytokine and growth factors |
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transcription factor critical to the signal transduction pathway of type I interferons |
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is a critical mediator in the activation of type I IFN-induced apoptosis |
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influences diverse cellular processes linked to RCAN1 by negatively affecting RCAN1 protein stability |
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is involved in the immunosuppressive function of human bone marrow-derived mesenchymal stem cells |
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is a positive modulator of the transcriptional response to type I interferons |
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in response to type I IFN, STAT2 is serine phosphorylated in the coiled-coil domain that when phosphorylated can negatively regulate the biological activities of type I IFNs |
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STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity |