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FLASH GENE

Symbol

STARD8

contributors: mct/npt - updated : 11-01-2008

HGNC name	StAR-related lipid transfer (START) domain containing 8
HGNC id	19161

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq13.1      Physical location : 67.867.510 - 67.945.682
Synonym name	START domain-containing RhoGAPs 3
	START domain containing 8
Synonym symbol(s)	KIAA0189, DLC3, GAP3, . STARTGAP3, DKFZp686H1668

DNA

TYPE	functioning gene
STRUCTURE	78.16 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 NM_001142503 15 - 4982 DLC3 alpha - 1103 - Durkin (2007) variant 2 NM_014725 14 - 4911 DLC-3 beta - 1023 - Kawai (2007), Durkin (2007) lacking the N-terminal sterile alpha motif domain variant 3 NM_001142504 14 - 4865 - - - Durkin (2007)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve       highly Reproductive female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to rattus regulator protein p122-RhoGAP

Homologene

FAMILY

START-GAP family proteins, DLC family

CATEGORY

regulatory , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	functions as a tumor suppressor gene
	having specific GAP activity on RhoA and CDC42, a common characteristic among the START-GAP family proteins
	deregulation of its expression may contribute to breast and prostate tumorigenesis (Durkin 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds both the Src homology 2 (SH2) domain and the phoshotyrosine binding (PTB) domain of tensin1, which is localized to the cytoplasmic side of focal adhesions
	may also interact with TNS4 via this sequence and target focal adhesions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   observed in kidney, lung, ovarian, uterine and breast cancer (Durkin 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS