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FLASH GENE
Symbol STARD5 contributors: mct - updated : 08-03-2017
HGNC name StAR-related lipid transfer (START) domain containing 5
HGNC id 18065
Location 15q25.1      Physical location : 81.605.013 - 81.616.524
Synonym name START domain containing 5
Synonym symbol(s) MGC10327
DNA
TYPE functioning gene
STRUCTURE 11.52 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1344 - 213 ubiquitous 2013 23872533
- - 1500 12.1 106 ubiquitous 2013 23872533
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly Homo sapiens
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidneytubuleconvoluted tubuleproximal tubulepredominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticbasophil Homo sapiens
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
not specificmast cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • STAR-related lipid transfer (START) domain
  • STARD4, STARD5 and STARD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization
  • HOMOLOGY
    interspecies Drosophila Cg13654
    intraspecies STARD4
    STARD6
    Homologene
    FAMILY
  • STARD4 sub-family of START domain containing proteins
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • in macrophages, STARD5 is found in the cytosol and maintains a loose association with the Golgi
  • mainly localized in the nucleus, and upon ER stress, it redistributes away from the nucleus, localizing prominently to the cytosol and membranes
  • within the epithelial cells of proximal renal tubules, STARD5 is present in the cytoplasm with high staining intensity along the apical brush-border membrane
  • basic FUNCTION
  • involved in the intracellular shuttling of sterols and other lipids
  • STARD5 functioning in kidney, specifically within proximal tubule cells, and playing likely a role in ER-associated cholesterol transport
  • role for STARD5 in cholesterol metabolism during the ER stress response
  • STAR and STARD6 bind cholesterol, but no cholesterol binding could be detected for STARD5
  • START domain containing protein specialized in the non-vesicular transport of lipids and sterols
  • is likely involved in the cellular response elicited by bile acids and offers many entry points to decipher its physiological role
  • playing likely a previously unappreciated role in cholesterol homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text cholesterol homeostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STAR/STARD3/STARD5, STARD5, PCTP/STARD10, STARD10 and COL4A3BP, respectively
  • binds primary bile acids
  • cell & other
  • cholesterol
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS