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FLASH GENE
Symbol STARD3NL contributors: - updated : 08-01-2007
HGNC name STARD3 N-terminal like
HGNC id 19169
Location 7p14-p13      Physical location : 38.217.932 - 38.270.269
Synonym name MLN64 N-terminal homolog
Synonym symbol(s) MENTHO, MGC3251
DNA
TYPE functioning gene
STRUCTURE 52.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineparathyroid   highly
Nervousbrain    
 nerve   highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved region of four transmembrane helices with three short intervening loops called the MENTAL domain (MLN64 N-terminal domain), mediating STARD3 and MENTHO homo- and hetero-interactions, targeting both proteins to late endosomes and binding cholesterol
  • a C-terminal domain homologous to StAR
  • HOMOLOGY
    intraspecies homolog to STARD3
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text late endosomal membrane protein
    basic FUNCTION
  • stimulating steroidogenesis in a placental system, which normally lacks StAR
  • involved in intracellular cholesterol transport, acting as discrete cholesterol-containing subdomains within the membrane of late endosomes where they may function in cholesterol transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein shared with conserved membrane-spanning MENTAL (MLN64 NH(2)-terminal) domain, that targets the protein to late endosome
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS