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FLASH GENE
Symbol STARD3 contributors: mct - updated : 05-12-2011
HGNC name START domain containing 3
HGNC id 17579
Location 17q12      Physical location : 37.793.332 - 37.820.454
Genatlas name metastatic lymph node (MLN) 64
Synonym name
  • metastatic axillary lymph nodes, cDNA64, amplified or expressed in breast cancer
  • steroidogenic acute regulatory protein related
  • retinal lutein-binding protein
  • Synonym symbol(s) CAB1, MLN64, es64, FLJ41370, R-LBP
    DNA
    TYPE functioning gene
    STRUCTURE 27.12 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2834 - 445 - -
    14 - 2780 - 427 - -
    15 - 2834 - 445 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestinesmall intestine  highly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin    
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal conserved membrane-spanning MENTAL (MLN64 NH(2)-terminal) domain shared with an unique protein called MENTHO (MLN64 NH(2)-terminal domain homologue) and targeting the protein to late endosome
  • one START domain, cholesterol-specific START domain [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain]
  • C-terminal domain with a cholesterol binding steroidogenic acute regulatory-related lipid transfer domain exposed to the cytoplasm
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text integral membrane protein
    basic FUNCTION
  • late endosomal cholesterol-binding membrane protein that binds and transports cholesterol
  • promoting steroidogenesis in placenta and brain
  • may facilitate lutein localization to a region of the cell subject to considerable oxidative stress (
  • through the MENTAL domain, playing a role in maintaining cholesterol at the membrane of late endosomes prior to its shuttle to cytoplasmic acceptor(s)
  • acting as discrete cholesterol-containing subdomains within the membrane of late endosomes where they may function in cholesterol transport
  • involved in actin-mediated dynamics of late endocytic organelles
  • retinal lutein-binding protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STAR/STARD3/STARD5, STARD5, PCTP/STARD10, STARD10 and COL4A3BP, respectively
  • differential cholesterol binding of the two most closely related START domain proteins STAR and STARD3
  • specific interactions of STARD3 with lutein
  • cell & other
    REGULATION
    induced by sterol depletion (methyl beta-cyclodextrin), enhancing STARD3, and represses STAR expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS