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FLASH GENE
Symbol STARD13 contributors: mct - updated : 13-04-2017
HGNC name StAR-related lipid transfer (START) domain containing 13
HGNC id 19164
Location 13q13.1      Physical location : 33.677.272 - 33.859.901
Synonym name
  • deleted in liver cancer 2
  • Rho GTPase activating protein (RHOGAP)on chromosome 13q12
  • START domain-containing RhoGAPs 2
  • START domain containing 13
  • Synonym symbol(s) GT650, 4902678, DLC2, STARTGAP2, FLJ37385, 46H23.2, ARHGAP37
    DNA
    TYPE functioning gene
    STRUCTURE 573.70 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5866 - 995 - 2006 16364308
  • isoform gamma
  • 14 - 5929 - 1113 - 2006 16364308
  • isoform alpha
  • 14 - 5836 - 1105 - 2006 16364308
  • isoform beta
  • 18 - 6276 - 1078 - 2006 16364308
    8 - 2877 - 646 - 2006 16364308
    - - 2825 - 687 - 2006 16364308
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
     spinal cord     Homo sapiens
    Reproductivefemale systembreastmammary gland highly
     male systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a“FAT (focal adhesion targeting)” region in the N-terminal half (localized in focal adhesions through the interaction between its FAT domain and tensin2) (Kawai 2009)
  • a sterile alpha-motif (SAM)
  • a distinct GAP domain
  • a tensin-SH2 domain-binding motif, SIYDNV (corresponding to residues 457–462
  • a conserved START (StAR related lipid transfer) domain
  • HOMOLOGY
    interspecies homolog to murine Stard13 (89.7pc)
    homolog to rattus Stard13 (88.4pc)
    Homologene
    FAMILY
  • START-GAP family proteins
  • RhoGAP proteins family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • having GTPase activator activity
  • acting as a tumor suppressor
  • suppresses Ras signaling and Ras-induced cellular transformation (Kawai 2009)
  • with DLC1 share the same molecular mechanism in targeting to focal adhesions (Kawai 2009)
  • modulating angiogenic responses in vascular endothelial cells by regulating cell attachment and migration (Lin 2010)
  • plays a key role in pain modulation during inflammation by suppressing the activation of RHOA and ERK to prevent an exaggerated pain response
  • STARD13 plays a role of a tumor suppressor in astrocytoma
  • is an essential regulator of pancreas tissue architecture in the mammalian embryo
  • acts by regulating RHO signalling spatially and temporally during pancreas development
  • Rho GTPase and its regulator, STARD13 RhoGAP, coordinate morphogenesis with growth in the developing pancreas
  • role of STARD13 as a tumor suppressor as well as a RHO GAP
  • is a tumor suppressor in breast cancer that regulates cell motility and invasion
  • STARD13 and KIF1B are thus central components of a signalling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with HMG CoA reductase , SWI/SNF, alpha-tubulin,and TAX1 binding protein (TAX1BP1)
  • negative regulator of RhoA and Cdc42 (Kawai 2009)
  • RHO-GAP that specifically inhibits the function of RHOA and CDC42
  • DLC1, and STARD13 are two novel interacting partner proteins of FKBP5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    suppresses the growth of breast tumor cells
    tumoral   deletion    
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dlc2(-/-) mice exhibit hyperalgesia to noxious thermal stimuli and inflammation-inducing chemicals, such as formalin and acetic acid