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FLASH GENE
Symbol STARD10 contributors: mct - updated : 08-03-2017
HGNC name START domain containing 10
HGNC id 10666
Location 11q13.4      Physical location : 72.465.774 - 72.504.750
Synonym name
  • similar to phosphatidylcholine transfer protein 2
  • serologically defined colon cancer antigen 28
  • antigen NY-CO-28
  • Synonym symbol(s) PCTP2, CGI-52, SDCCAG28, NY-CO-28
    DNA
    TYPE functioning gene
    STRUCTURE 38.98 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OR7E10P 8p22 olfactory receptor, family 7, subfamily E, member 10 pseudogene RNF121 11q13.3 ring finger protein 121 IL18BP 11q13 interleukin 18 binding protein NUMA1 11q13.3-q13.5 nuclear mitotic apparatus protein 1 LOC220074 11q13.3 Hypothetical 55.1 kDa protein F09G8.5 in chromosome III FLJ20625 11q13.3 hypothetical protein FLJ20625 LOC390220 11 similar to Catechol-O-methyltransferase DKFZP564M082 11q13.3 DKFZP564M082 protein FOLR3 11q13 folate receptor 3 (gamma) LOC390221 11 similar to folate receptor 1 precursor LOC390222 11 hypothetical gene supported by U08471; Z32564; NM_000804 FOLR1 11q13.3-q13.5 folate receptor 1 (adult) FOLR2 11q13.3-q13.5 folate receptor 2 (fetal) INPPL1 11q23 inositol polyphosphate phosphatase-like 1 PHOX2A 11q13.3-q13.4 paired-like (aristaless) homeobox 2a LOC220077 11q13.3 hypothetical gene supported by AF229166 LOC390223 11 similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) SKD3 11q13.3 suppressor of potassium transport defect 3 ART2P 11q13 ADP-ribosyltransferase 2 pseudogene (RT6 antigen homolog, rat) PDE2A 11cen-q12.1 phosphodiesterase 2A, cGMP-stimulated CENTD2 11q13.3 centaurin, delta 2 STARD10 11q13 START domain containing 10 FLJ00012 11q13.3 hypothetical protein FLJ00012 KIAA0769 11q13.2 hypothetical protein FLJ00012 P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1988 - 291 - 2005 15911624
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Mus musculus
     liver   highly Homo sapiens
    Reproductivemale systemtestis    Mus musculus
    Urinarykidney     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines various cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a steroidogenic acute regulatory protein (StAR)-related lipid transfer (“StART”) domain
  • HOMOLOGY
    Homologene
    FAMILY steroidogenic acute regulatory protein (StAR)-related lipid transfer protein family
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be required in the acute regulation of steroidogenesis
  • may function in the secretion of phospholipids into the bile
  • is involved in regulating bile acid metabolism through the modulation of PPARA-mediated mechanism
  • phospholipid transfer protein possessing a steroidogenic acute regulatory protein (StAR)-related lipid transfer (“StART”) domain that facilitates the transport of phosphatidylcholine and phosphatidylethanolamine between intracellular membranes
  • is required for normal insulin secretion, though its deletion enhances proinsulin processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STAR/STARD3/STARD5, STARD5, PCTP/STARD10, STARD10 and COL4A3BP, respectively
  • LPCAT1 interacts with STARD10, and AAs 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction
  • cell & other
    REGULATION
    Phosphorylated by phosphorylated on serine 284, and C-terminal STARD10 phosphorylation on serine 284 regulates its association with cellular membranes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in STARD10 expression in the beta cells associated to type 2 diabetes
    tumoral     --over  
    in breast cancer
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • fecal excretion of bile acids was significantly increased in Stard10(-/-) mice