basic FUNCTION
| docking protein |
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substrate of breast tumor kinase, an src-type non-receptor tyrosine kinase |
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STAP2 influences PTK2 protein levels through recruitment of E3 ubiquitin ligase CBL to PTK2 |
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critical contribution of STAP2 in BCR-ABL activity, suggesting that STAP2 might be an important candidate for drug development for patients with chronic myeloid leukemia (CML) |
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participates in activation-induced cell death in T cells |
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is a novel participant in the regulation of T cell apoptosis after stimulation |
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regulates both the innate and adaptive immune systems |
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adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules |
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physiological role of STAP2 in mast cell function, a key mediator of IgE-associated allergic responses |
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is an adaptor molecule regulating several signaling pathways, including TLRs and cytokine/chemokine receptors in immune cells |