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FLASH GENE
Symbol STAP2 contributors: mct - updated : 01-12-2017
HGNC name signal transducing adaptor family member 2
HGNC id 30430
Location 19p13.3      Physical location : 4.324.040 - 4.338.847
Synonym name
  • brk kinase substrate
  • breast tumor kinase substrate
  • signal-transducing adaptor protein-2
  • Synonym symbol(s) BKS, STAP-2, FLJ20234
    DNA
    TYPE functioning gene
    STRUCTURE 14.83 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1557 49.5 449 - 2017 28478037
    13 - 1419 - 403 - 2017 28478037
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • pleckstrin and src homology (SH2)-like domains as well as YXXQ motif, and and proline-rich regions in its C-terminal
  • HOMOLOGY
    interspecies homolog to murine Stap2 (70.2pc)
    homolog to rattus Stap2 (71.2pc)
    Homologene
    FAMILY STAP adaptor proteins
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • docking protein
  • substrate of breast tumor kinase, an src-type non-receptor tyrosine kinase
  • STAP2 influences PTK2 protein levels through recruitment of E3 ubiquitin ligase CBL to PTK2
  • critical contribution of STAP2 in BCR-ABL activity, suggesting that STAP2 might be an important candidate for drug development for patients with chronic myeloid leukemia (CML)
  • participates in activation-induced cell death in T cells
  • is a novel participant in the regulation of T cell apoptosis after stimulation
  • regulates both the innate and adaptive immune systems
  • adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules
  • physiological role of STAP2 in mast cell function, a key mediator of IgE-associated allergic responses
  • is an adaptor molecule regulating several signaling pathways, including TLRs and cytokine/chemokine receptors in immune cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CBL
  • STAP2 upregulated PTK6-mediated activation of STAT3 in breast cancer cells
  • STAP2 bound to BCR-ABL, and BCR and ABL proteins, depending on the STAP2 Src homology 2-like domain
  • STAP2 binds to MYD88 and inhibitor (I)kappaB kinase CHUK/IKBKB in TLR4 signaling, and enhances the production of inflammatory cytokines in macrophages
  • contribution of CCR7 to STAP2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells
  • PTK2B/STAP2 interaction is a novel mechanism to regulate CXCL12-dependent T-cell chemotaxis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    might be an important candidate for drug development for patients with chronic myeloid leukemia (CML)
    allergy  
    manipulation of STAP2 expression in mast cells may control the pathogenesis of allergic diseases and have the potential for treating patients with allergy
    ANIMAL & CELL MODELS