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FLASH GENE
Symbol STAMBPL1 contributors: - updated : 06-04-2007
HGNC name associated molecule with the SH3 domain of STAM (AMSH) like protein
HGNC id 24105
Location 10q23.33      Physical location : 90.640.025 - 90.683.242
Synonym name
  • associated molecule with the SH3 domain of STAM (AMSH) like protein
  • AMSH-like protease
  • STAM-binding protein-like 1
  • Synonym symbol(s) KIAA1373, AMSH-FP, AMSH-LP, FLJ31524, ALMalpha, bA399O19.2
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 43.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative nuclear localization signal (NLS)
  • a Mpr/Pad1/N-terminal (MPN) domain
  • a Jab1/MPN domain metalloenzyme (JAMM) motif
  • a clathrin-binding site
  • HOMOLOGY
    intraspecies homolog to STAMBP
    Homologene
    FAMILY peptidase M67C family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as the regulatory subunit of the 26 proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins
  • deubiquitinating enzyme that acts on early endosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein are anchored with STAMBP on the early endosomal membrane via interaction with the clathrin coat (bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS