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FLASH GENE
Symbol STAM2 contributors: mct/ - updated : 16-02-2015
HGNC name signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
HGNC id 11358
Location 2q23.3      Physical location : 152.973.315 - 153.032.506
Synonym name
  • signal transducing adaptor molecule 2A
  • Hrs-binding protein
  • HSE1 homolog
  • Synonym symbol(s) Hbp, STAM2A, STAM2B, DKFZp564C047, STAP-2
    DNA
    TYPE functioning gene
    STRUCTURE 59.20 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5701 - 525 - 2009 19054391
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscular    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SH3 domain
  • a VHS domains, binding to ubiquitin via its hydrophobic patch consisting of N-terminus of helix 2 and C-terminus of helix 4
  • immunoreceptor tyrosine based activation motif (ITAM)
  • PTPN1 binding sites
  • HOMOLOGY
    interspecies ortholog to murine Stam2
    Homologene
    FAMILY
  • STAM family
  • CATEGORY adaptor , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localize prominently to early exocytic compartments and profoundly regulate Golgi morphology
  • basic FUNCTION
  • DNA synthesis
  • cytokine-mediated signal transduction (potential cytokine receptor signaling)
  • associates with hepatocyte growth factor-regulated substrate and plays a key role in the endosomal sorting machinery
  • involved in growth factor and cytokine signaling as well as receptor degradation, and they form complexes with a number of endocytic proteins, including HARS and EPS15
  • function prominently in ER-to-Golgi trafficking, most likely through direct interactions with the COPII complex
  • endosomal protein involved in sorting activated RTKs for lysosomal degradation
  • involved in growth factor and cytokine signaling as well as receptor degradation, and they form complexes with a number of endocytic proteins, including HGS and EPS15
  • in addition to their roles in signaling and endocytosis, function prominently in ER-to-Golgi trafficking, most likely through direct interactions with the COPII complex
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Janus kinases (JAK2, JAK3)
  • CSF2
  • interacting with RIN1
  • binds to MYD88 and IKK-alpha/beta, and modulates NF-kappaB signaling in macrophages
  • directly binds to CSF1 and interferes with the PI3K signaling, which leads to macrophage motility
  • substrate of PTPN1
  • STAMBP interacts with signal transducing adapter molecule (STAM) 1 or STAM2, which enhances the activity of STAMBP through an unknown mechanism
  • cell & other
    REGULATION
    induced by tyrosine phosphorylation EGF,PDGF,IL3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS