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FLASH GENE
Symbol STAM contributors: mct/npt - updated : 27-06-2018
HGNC name signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
HGNC id 11357
Location 10p12.33      Physical location : 17.686.123 - 17.757.907
Synonym name signal transducing adaptor molecule 1
Synonym symbol(s) STAM1, DKFZp686J2352, STAM-11
DNA
TYPE functioning gene
STRUCTURE 72.70 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD) NMT2 10p12.33-p12.32 N-myristoyltransferase 2 LOC221061 10p13 hypothetical protein LOC221061 ITGA8 10p13 integrin, alpha 8 FLJ13397 10p13 hypothetical protein FLJ13397 PTER 10p12 phosphotriesterase related LOC389941 10 similar to Gliacolin RSU1 10p13 Ras suppressor protein 1 CUBN 10p12.1 cubilin (intrinsic factor-cobalamin receptor) DNMT2 10p15.1 DNA (cytosine-5-)-methyltransferase 2 VIM 10p13 vimentin ST8SIA-VI 10p13 alpha 2,8-sialyltransferase PTPLA 10p14-p13 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a STAM 10p14-p13 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 LOC340843 10p13 similar to protein of unknown function LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit NOPD1 10p13 nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 ARL8 10p13 ADP-ribosylation factor-like 8 LOC389942 10 similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing factor) LOC387635 10 similar to ubiquitin-conjugating enzyme E2 variant 1 isoform a; DNA-binding protein LOC340895 10p12.33 similar to apical early endosomal glycoprotein precursor LOC387636 10 LOC387636 PLXDC2 10p12.33 plexin domain containing 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3882 59 540 - 2016 27789711
15 - 3986 - 490 - 2016 27789711
15 - 3994 - 490 - 2016 27789711
15 - 4025 - 412 - 2016 27789711
13 - 3786 - 508 - 2016 27789711
12 - 3710 - 429 - 2016 27789711
12 - 3940 - 412 - 2016 27789711
13 - 3797 - 490 - 2016 27789711
11 - 3625 - 443 - 2016 27789711
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunethymus   highly
Nervousbraindiencephalonamygdala  
 nerve   highly
 spinal cord    
Reproductivemale systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Src homology 3 (SH3) domain
  • one immunoreceptor tyrosine-based activation motif (ITAM)
  • N-terminal 191 AAs which contain both VHS and ubiquitin binding motif (UIM),(VHS domains, binding to ubiquitin via its hydrophobic patch consisting of N-terminus of helix 2 and C-terminus of helix 4)
  • a coiled-coil region that overlaps with ITAM required for interactions TIMM8A-STAM
  • HOMOLOGY
    Homologene
    FAMILY
  • STAM family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localizes predominantly to early endosomes (localize to endosomal membranes)
  • localize prominently to early exocytic compartments and profoundly regulate Golgi morphology
  • basic FUNCTION
  • signal-transducin adaptor molecule involved in cytokine-mediated signal transduction
  • involved in growth factor and cytokine signaling as well as receptor degradation, and they form complexes with a number of endocytic proteins, including HGS and EPS15
  • in addition to their roles in signaling and endocytosis, function prominently in ER-to-Golgi trafficking, most likely through direct interactions with the COPII complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule) form a heterodimeric complex that associates with endosomal membranes and is tyrosine-phosphorylated in response to a variety of growth
  • ESCRT-0 complex is composed of two subunits, HGS and STAM, both of which can engage ubiquitinylated substrates destined for lysosomal degradation
  • crucial regulatory axis for the ventral axonal trajectory of developing spinal MNs, consisting of the ISL1-LHX3 complex, STAM1 and CXCR4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with several cytoplasmic proteins involved in cell signaling and endosomal trafficking (with TIMM8A)
  • USP8Y binding partner
  • STAM-STAMBP interaction facilitates the deubiquitination activity in the C-terminal STAMBP
  • associating with USP8
  • interaction between ITCH and STAM and the ligase activity of ITCH are essential for ERK-1/2 activation
  • LITAF interacted and colocalized with endosomal sorting complex required for transport (ESCRT) components STAM, HGS, and TSG101 on early endosomes and functioned with the ESCRT machinery in the control of endosome-to-lysosome trafficking
  • STAMBP interacts with signal transducing adapter molecule (STAM) 1 or STAM2, which enhances the activity of STAMBP through an unknown mechanism
  • ARRB1 and STAM cooperate to promote focal adhesion kinase autophosphorylation and chemotaxis via the chemokine receptor CXCR4
  • USP8 interacts with and deubiquitinates SEC31A; the interaction was mediated by the adaptor protein STAM
  • cell & other
    REGULATION
    induced by interleukin IL2
    Other phosphorylated by the JAK kinases upon cytokine stimulation (function of this protein is likely as an adaptor molecule involved in the downstream signaling of cytokine receptors)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS