SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm,nuclear bodies
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| intracellular,nucleus,chromatin/chromosome
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basic FUNCTION
| transcriptional target for Tp53, mediating Tp53-dependent apoptosis |
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role for STAG/Scc3 in transcriptional regulation |
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cohesin(STAG1) and cohesin(STAG2) are differentially required for telomere and centromere cohesion, respectively |
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involvement in sister chromatid cohesion |
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STAG1 and STAG2 participate in the DNA damage response, coordinately protecting genome integrity in human cells through unique ways |
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CTCF and STAG1 have multiple roles in the regulation of gene expression during erythropoiesis including transcriptional regulation at gene promoters and maintenance of chromatin architecture 7) |
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STAG1 and STAG2 share high sequence identity, encode mutually exclusive cohesin subunits and retain partially overlapping functions |
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cohesin ring is a protein complex composed of four core subunits: SMC1A, SMC3, RAD21 and STAG1/STAG2 and is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation |
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STAG1 is required for telomere cohesion and STAG2 for centromere cohesion |
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STAG1 preferentially contributes to the stabilization of topologically associating domain boundaries together with CTCF, whereas STAG2 promotes cell-type-specific contacts between enhancers and promoters independently of CTCF |