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FLASH GENE
Symbol ST8SIA4 contributors: - updated : 22-04-2006
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
HGNC id 10871
Location 5q21      Physical location : 100.142.639 - 100.238.987
Synonym name
  • polysialytransferase
  • sialyltransferase 8D (alpha-2, 8-polysialyltransferase)
  • CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase
    • Synonym symbol(s) PST, PST1, ST8SIA-IV, SIAT8D, MGC61459
    EC.number 2.4.99.8
    DNA
    TYPE functioning gene
    STRUCTURE 91.00 kb     5 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 6051 - 359 - Mendiratta
    - - 1887 - 168 - Mendiratta
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
     thymus   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text highly in brain, lung, kidney, lowly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Siat8d
    Homologene
    FAMILY glycosyltransferase family 29
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • alpha-N-neuraminide-alpha-2,8-sialyltransferase (glycosylation), facilitating neurite outgrowth
  • catalyzing the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulation ofpolysialic acid during oligodendrocyte differentiation is a prerequisite for efficient myelination by mature oligodendrocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS