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FLASH GENE

Symbol

ST8SIA3

contributors: - updated : 22-04-2006

HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
HGNC id	14269

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.31      Physical location : 55.019.720 - 55.036.159
Synonym name	sialyltransferase 8C (alpha2,3Galbeta1, 4GlcNAcalpha 2,8-sialyltransferase)
Synonym symbol(s)	ST8Sia III, SIAT8C
EC.number	2.4.99.-

DNA

TYPE	functioning gene
STRUCTURE	9.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V2 - - 1248 44.1 380 - Angata V1 - - 3493 44.1 380 - Kim

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain and liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Siat8c
	homolog to murine Siat8c

Homologene

FAMILY

vertebrate sialyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein
	Golgi (potential)

basic FUNCTION	playing a role in synthesis of 'c'-series gangliosides
	adding polysialic and oligosialic acid to sialylated N-acetyllactosaminyl oligosaccharides
	autopolysialylation

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

development

text	neuronal development
	N-glycan processing
	glycosylation

PATHWAY

metabolism

carbohydrate

signaling

oligosaccharide metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

developmentally and tissue-specifically regulated

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS