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FLASH GENE

Symbol

ST7L

contributors: - updated : 10-01-2006

HGNC name	suppression of tumorigenicity 7 like
HGNC id	18441

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p13      Physical location : 113.066.141 - 113.162.040
Synonym symbol(s)	ST7R, STLR, FLJ11657, FLJ20284

DNA

TYPE	like-sequence
SPECIAL FEATURE	component of a cluster, tail to tail
text	in tail-to-tail manner with an interval of less than 5.0-kb. ST7L-WNT2B
STRUCTURE	84.00 kb     15 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ST7L I1 - splicing 4552 - 575 - Katoh ST7L I2 - splicing 4502 - 558 - Katoh missing an internal region, ST7L I3 - splicing 4459 - 544 - Katoh missing an internal region ST7L I4 - splicing 2142 - 555 - Katoh a distinct and shorter C-terminus, ST7L I5 - splicing 4508 - 555 - Katoh a distinct C-terminus compared to isoform 1

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve cranial nerve optic nerve     Reproductive male system prostate

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	umbilical cord blood

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

leucine zipper domain and three tyrosine-phosphorylation sites

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,nucleus

basic FUNCTION

tumor suppressor gene

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS