Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ST7 contributors: - updated : 08-09-2005
HGNC name suppression of tumorigenicity 7
HGNC id 11351
Location 7q31.1-q33      Physical location : 116.593.380 - 116.870.073
Synonym name tumor suppressor gene(s), chromosome 7
Synonym symbol(s) FAM4A1, RAY1, HELG, SEN4, ETS7q, TSG7A
DNA
TYPE functioning gene
STRUCTURE 130.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
cytosine-phosphate-guanine/HTF
text structure 16 exons including 16a,16b
MAPPING cloned Y linked N status confirmed
Map cen - D7S496 - D7S2459 - D7S2425 - D7S687 - D7S486 - D7S522 - CAV2 - CAV1 - MET - CAPZA2 - D7S2460 - ST7 - WNT2 - D7S633 - ASZ1 - D7S677 - CFTR - D7S480 - D7S648 - D7S490 - D7S487 - D7S2527 - D7S530 - D7S495 - qter
Authors Zenklushausen (95), Lin (96), Edelson (97), Huang (98), Vincent (00)
Physical map
DOCK4 7q21.13-q31.1 Ca2+-dependent activator protein for secretion 2 ZNF277 7q31.1 zinc finger protein (C2H2 type) 277 IFRD1 7q31 interferon-related developmental regulator 1 FLJ39575 7q31.1 hypothetical protein FLJ39575 NPM1P14 7q31.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 14 FLJ13576 7q31.32 hypothetical protein FLJ13576 FLJ31818 7q31.1 hypothetical protein FLJ31818 GPR85 7q31 G protein-coupled receptor 85 LOC389548 7 hypothetical gene supported by BX537645 PPP1R3A 7q11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) FOXP2 7q31 forkhead box P2 HIC 7q31.1 forkhead box P2 TFEC 7q31.2 transcription factor EC TES 7q31.2 testis derived transcript (3 LIM domains) CAV2 7q31.1-q31.2 caveolin 2 CAV1 7q31.2-q31.3 caveolin 1, caveolae protein, 22kDa MET 7q31.2-q31.3 met proto-oncogene (hepatocyte growth factor receptor) CAPZA2 7q31.2-q31.3 capping protein (actin filament) muscle Z-line, alpha 2 ST7 7q31.1-q31.3 suppression of tumorigenicity 7 WNT2 7q31 wingless-type MMTV integration site family member 2 GASZ 7q31.31 GASZ CFTR 7q31.3 cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) CORTBP2 7q31.3 cortactin binding protein 2 LSM8 7q31.1-q31.3 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) ANKRD7 7q31 ankyrin repeat domain 7 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2061 - 554 widely Vincent, Lu
exon 7, exon 16a
- splicing 2709 - 585 - Vincent, Ogata, Lu
exon 7, 16b
- splicing 1698 - 502 widely Zenclusen
- splicing 2180 - 534 widely Zenclusen
- splicing 2110 - 511 - Zenausen
econs 2 to 16
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
 liver    
 mouth   highly
Endocrinepancreas    
Reproductivefemale systemuteruscervix highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure twelve alpha helices with 4 turns
HOMOLOGY
interspecies homolog to murine Mray1
homolog to Drosophila Dray1
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION tumor suppressor gene(s)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in breast tumor and primary breast carcinoma, invasive epithelial ovarian cancer, myeloid disorder, acute lymphocytic leukemia
tumoral   LOH    
in acute myelogenous leukemia, acute lymphocytic leukemia, breast cancer, prostate cancer, ovarian tumor, follicular and papillary thyroid tumors
tumoral   LOH    
in sporadic renal cell carcinoma, pancreatic carcinoma, head and neck sqamous cell carcinoma, esophageal and colon carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS