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FLASH GENE
Symbol ST6GALNAC5 contributors: mct - updated : 11-10-2010
HGNC name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
HGNC id 19342
Location 1p31.1      Physical location : 77.333.185 - 77.529.735
Synonym name
  • similar to sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
  • GD1 alpha synthase
  • GalNAc alpha-2,6-sialyltransferase V
  • sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E
    • Synonym symbol(s) MGC3184, ST6GalNAcV, SIAT7E
    EC.number 2.4.99.-
    DNA
    TYPE functioning gene
    STRUCTURE 198.28 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2048 38.4 336 - - 10521438
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • glycosyltransferase family 29
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • with PTGS2 and HBEGF, are mediators of cancer cell passage through the blood-brain barrier
  • catalyzes the formation of the terminal alpha2,6-sialic acid linkages on gangliosides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by all-trans-retinoic acid (RA) (RA is a significant regulator of GALM and other galactose-related genes in myeloid-monocytic cells, which could affect energy utilization and synthesis of cell-surface glycoproteins or glycolipids involved in cell motility, adhesion, and/or functional properties)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical cancer
    tumoral     --over  
    in tumorigenic, glioma cells, leading to enhanced phosphorylation of HSPA8/HSC70 in response to attachment to fibronectin, intimately involved in tumor cell adhesion, motility, and invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target modulation of the synthesis of specific glioma cell-surface glycosphingolipids alters invasivity in a manner that may have significant therapeutic potential
    ANIMAL & CELL MODELS