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FLASH GENE

Symbol

ST6GALNAC4

contributors: npt - updated : 03-07-2002

HGNC name	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
HGNC id	17846

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.1      Physical location : 130.670.165 - 130.679.305
Synonym name	sialyltransferase 3c
	sialyltransferase 3 (alpha-N-acetylgalactosamide alpha 2,6)
	sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)
Synonym symbol(s)	SIAT3C, SIAT7D, ST6GALNACIV
EC.number	2.4.99.7

DNA

TYPE	functioning gene
STRUCTURE	9.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1717 34.2 302 widely - variant 2 - - 1630 - 218 lower in£brain, heart, skeletal muscle -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	wide variety of cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	single transmembrane segment and the so-called sialyl motif
	7AA cytoplasmic domain
	18AA transmembrane domain
	small catalytic domain of 277AA
	sialyl motifs L,S and VS

HOMOLOGY

interspecies	ortholog to fugu SIAT3C
	homolog to murine Siat7d

Homologene

FAMILY

glycosyltransferase family 29

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II membrane protein

basic FUNCTION

transfering sialic acid from CMP-Neu5Ac forming an alpha-2,6 linkage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

glycolipid metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS