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FLASH GENE
Symbol ST6GALNAC2 contributors: mlc - updated : 06-06-2006
HGNC name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
HGNC id 10867
Location 17q25      Physical location : 74.561.461 - 74.582.145
Synonym name
  • sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B
  • sialyltransferase 7B, putative
  • sialyltransferase-like 1
  • Synonym symbol(s) SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM , STM
    EC.number 2.4.99.7
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Hearing/Equilibriumear   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    the L- and S- sialylmotifs
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzing the synthesis of O-glycans
  • catalyzing the synthesis of O-glycans and the formation of mucin-related antigens in breast cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    Susceptibility to IgA nephropathy
    Variant & Polymorphism other functional regulatory variant that may contribute to the genetic susceptibility in desialylation of IgA1 molecules causative pathogenesis of IgA nephropathy
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS