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FLASH GENE
Symbol ST6GAL2 contributors: - updated : 30-03-2005
HGNC name ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
HGNC id 10861
Location 2q11.2-q12.1      Physical location : 107.418.057 - 107.503.563
Synonym symbol(s) SIAT2, KIAA1877, ST6GalII
EC.number 2.4.99.1
DNA
TYPE functioning gene
STRUCTURE 85.00 kb     8 Exon(s)
motif repetitive sequence   ALU
text structure an Alu repetitive element in the 3-prime untranslated region
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Reproductivefemale systemovary  moderately
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal hydrophobic sequence characteristic of type 2 transmembrane proteins
  • a stem region
  • sialyl motifs L (long)
  • sialyl motifs S (short)
  • sialyl motifs VS (very short)
  • four potential N-glycosylation sites
    • HOMOLOGY
    interspecies ortholog to rattus St6gal2
    ortholog to murine St6gal2
    intraspecies paralog to ST6GAL1
    Homologene
    FAMILY beta-galactoside alpha2, 6-sialyltransferase (ST6Gal) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 2 transmembrane protein
    • basic FUNCTION
  • catalyzing the transfer of sialic acid from CMP-sialic acid to an acceptor carbohydrate, usually to the terminal ends of carbohydrate chains
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • oligosaccharide metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS