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FLASH GENE

Symbol

ST3GAL4

contributors: - updated : 14-03-2006

HGNC name	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
HGNC id	10864

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23-q24      Physical location : 126.226.095 - 126.284.531
Synonym name	sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)
Synonym symbol(s)	CGS23, NANTA3, SIAT4, SIAT4C
EC.number	2.4.99.4

DNA

TYPE	functioning gene
STRUCTURE	58.00 kb     11 Exon(s)

regulatory sequence	cytosine-phosphate-guanine/HTF
text structure	no TATA,no CAAT

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed long A (A1) - splicing 987 - 328 - Kitagawa, Grahn short A (A2) - splicing 957 - 322 placenta Kitagawa, Grahn long B (B1) - splicing initiation site 999 38 333 placenta Kitagawa long B2 - initiation site 2000 - - placenta Kitagawa long B3 - initiation site 2000 - - placenta Kitagawa

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Reproductive female system placenta     highly   female system uterus cervix   highly   male system testis     specific

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	highly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N terminal signal-anchor sequence, central sialyl motif

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Siat4c
	homolog to C.elegans F14b6.6

Homologene

FAMILY	vertebrate sialytransferase family
	glycosyltransferase family 29

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein
	membrane-bound form in tran-cisternae of Golgi
	soluble form in body fluids

basic FUNCTION	transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids
	playing a role in synthesis of carbohydrate antigens lex, ley and sialyl-lex
	acting on the corresponding 1.3-galactosyl derivative

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

text	glycosylation

PATHWAY

metabolism

lipid/lipoprotein , metal

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS