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FLASH GENE
Symbol ST3GAL4 contributors: - updated : 14-03-2006
HGNC name ST3 beta-galactoside alpha-2,3-sialyltransferase 4
HGNC id 10864
Location 11q23-q24      Physical location : 126.226.095 - 126.284.531
Synonym name sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)
Synonym symbol(s) CGS23, NANTA3, SIAT4, SIAT4C
EC.number 2.4.99.4
DNA
TYPE functioning gene
STRUCTURE 58.00 kb     11 Exon(s)
regulatory sequence cytosine-phosphate-guanine/HTF
text structure no TATA,no CAAT
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 987 - 328 - Kitagawa, Grahn
- splicing 957 - 322 placenta Kitagawa, Grahn
- splicing initiation site 999 38 333 placenta Kitagawa
- initiation site 2000 - - placenta Kitagawa
- initiation site 2000 - - placenta Kitagawa
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Reproductivefemale systemplacenta  highly
 female systemuteruscervix highly
 male systemtestis  specific
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text highly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal signal-anchor sequence, central sialyl motif
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Siat4c
homolog to C.elegans F14b6.6
Homologene
FAMILY
  • vertebrate sialytransferase family
  • glycosyltransferase family 29
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • membrane-bound form in tran-cisternae of Golgi
  • soluble form in body fluids
  • basic FUNCTION
  • transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids
  • playing a role in synthesis of carbohydrate antigens lex, ley and sialyl-lex
  • acting on the corresponding 1.3-galactosyl derivative
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text glycosylation
    PATHWAY
    metabolism lipid/lipoprotein , metal
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS