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FLASH GENE
Symbol ST3GAL1 contributors: - updated : 04-11-2005
HGNC name sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
HGNC id 10862
Location 8q24.22      Physical location : 134.467.090 - 134.584.183
Synonym name
  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase
  • Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
  • Synonym symbol(s) SIATFL, SIAT4A, Gal-NAc6S, MGC9183, ST3GalA.1, ST3GalIA, ST3O
    EC.number 2.4.99.4
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     7 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map cen - D8S529 - ST3GAL1 - D8S1710 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text poorly in heart, highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Siat4a
    homolog to C.elegans C47f8.6
    Homologene
    FAMILY
  • glycosyltransferase family 29
  • vertebrate sialtransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II membrane protein
  • membrane-bound form in trans-cisternae of Golgi
  • soluble form in body fluids
  • basic FUNCTION
  • catalyzing the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text glycosylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS