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FLASH GENE
Symbol ST3 contributors: mct/npt - updated : 12/11/2008
HGNC name suppression of tumorigenicity 3
HGNC id 11348
Location 11q13-q23      Physical location : -
Synonym name tumor suppressor gene(s), chromosome 11 (see SDHD)
Synonym symbol(s) CCTS, TSHL, TSG11F
EC.number 2.5.1.18
DNA
TYPE anonymous DNA segment
MAPPING cloned Y linked N status confirmed
Map cen - D11S901 - D11S1354 - D11S917 - D11S35 - D11S940 - [D11S1394 - ((D11S2000 - D11S2179 - D11S1818 - PPP2R1B - D11S897 - NCAM1 - ZNF145 - D11S1391 - D11S897 )) - D11S1987 ] - D11S1340 - D11S29 - D11S1356 - CD3D - D11S924 - D11S528 - RNF26 - USP2 - TRIM29 - POU2F3 - ((D11S925 - D11S1336 - D11S1316 ))] - D11S933 - CHEK1 - D11S990 - D11S1896 - D11S934 - ETS1 - D11S912 - D11S969 - D11S439 - qter
Authors Negrini (93), Rasio (95), Davis (96), Gabra (96), Koreth (97), Monaco (97), Golberg (00), Zhang (05)
Text [LOH in lung,brain, ovarian carcinoma],[melanoma suppressor of TSG11F ], also interval for PPP2R1B : Wang (98),((breast)), two loci : di Lasio (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • candidate gene ST14 (SNC19)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • tumor suppressor gene(s)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in B cell prolymphocytic leukemia, colorectal carcinoma, cutaneous malignant melanoma, chronic lymphocytic leukemia, mantle cell lymphoma, childhood acute lymphoblastic leukemia, B cell chronic lymphocytic leukemia, T prolymphocytic leukemia
    tumoral   LOH    
    in lung cancer, ovarian cancer, breast carcinoma early onset and reduced survival, cervical, esophageal squamous cell carcinoma, paragangliomas of the head and neck, ataxia telangiectasia, Cowden disease,
    tumoral   LOH    
    in adenocarcinoma of the stomach, nasopharyngeal carcinoma, lung adenocarcinoma, malignant melanoma (LOH often including ATM locus, see symbol), see also LPD, LOH11CR2A, PGL1, MTCL
    tumoral   LOH    
    in pheochromocytoma and paraganglioma (Sun 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS