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FLASH GENE
Symbol ST18 contributors: mct/npt - updated : 30/10/2008
HGNC name suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
HGNC id 18695
Location 8q11.21-q11.23      Physical location : 53.023.391 - 53.322.439
Synonym name
  • zinc finger protein 387
  • suppression of tumorigenicity 18
  • Synonym symbol(s) KIAA0535, ZNF387, NZF3
    DNA
    TYPE functioning gene
    STRUCTURE 298.50 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC137133 8q11.22 similar to phosphoserine aminotransferase isoform 1 LOC389656 8 LOC389656 SNTG1 8q11.2-q12 syntrophin, gamma 1 HCP22 8q11.22 cytochrome c, somatic pseudogene FLJ25471 8q11.22 hypothetical protein FLJ25471 BTF3P1 8q11.22 basic transcription factor 3, pseudogene 1 LOC115294 8q11.22 similar to hypothetical protein FLJ10883 LOC389657 8 LOC389657 ST18 8q11.21 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) LOC389658 8 similar to RPLK9433 RB1CC1 8p22-q11.23 RB1-inducible coiled-coil 1 GPR7 10q11.2-q21.1 G protein-coupled receptor 7 LOC392219 8 similar to ring finger protein 2 OPRK1 8q11.2 opioid receptor, kappa 1 LOC392220 8 similar to L21 ribosomal protein MAPK6PS1 8q11.23 similar to L21 ribosomal protein ATP6V1H 8p22-q22.3 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H RGS20 8q11.22-q11.23 regulator of G-protein signalling 20 TCEA1 3p22-p21.3 transcription elongation factor A (SII), 1 LYPLA1 6pter-p25.1 lysophospholipase I TDGF5 8q11.23 teratocarcinoma-derived growth factor 5, pseudogene MRPL15 8q11.2-q13 mitochondrial ribosomal protein L15 LOC392221 8 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 6330 115 1047 - Jandrig (2004
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunespleen    
    Nervousbrain    
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text in the developing CNS
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six fingers of the C2HC type (configuration Cys-X5-Cys-X12-His-X4-Cys)
  • a SMC domain
  • HOMOLOGY
    interspecies ortholog to murine St18
    homolog to rattus St18
    Homologene
    FAMILY
  • myelin transcription factor 1 (Myt1) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressor of tumorogenicity (may be the same than TSG8E)
  • having the potential to act as transcriptional regulator
  • may have a regulatory function in a specific phase during neuronal differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    breast carcinoma
    tumoral     --low  
    a 160 bp region within the promoter is hypermethylated in about 80p100 of the breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS