Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SSX5 contributors: mct/npt - updated : 25-03-2009
HGNC name synovial sarcoma, X breakpoint 5
HGNC id 11339
Location Xp11.23      Physical location : 48.045.655 - 48.056.199
Synonym symbol(s) MGC9494
DNA
TYPE functioning gene
STRUCTURE 10.54 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF157 Xp11.23 zinc finger protein 157 (HZF22) ZNF41 Xp11.23 zinc finger protein 41 LOC389850 X similar to hypothetical protein, MGC:7199 TIMP1 Xp11.23 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ARAF1 Xp11.3-p11.23 v-raf murine sarcoma 3611 viral oncogene homolog 1 SYN1 Xp11.23 synapsin I PFC Xp11.3-p11.23 properdin P factor, complement ELK1 Xp11.3-p11.23 ELK1, member of ETS oncogene family UXT Xp11.23-p11.22 ubiquitously-expressed transcript LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20) ZNF21 Xp11.23 zinc finger protein 21 (KOX 14) LOC389852 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5 LOC392462 X similar to synovial sarcoma, X breakpoint 6 SSX1 Xp11.23-p11.22 synovial sarcoma, X breakpoint 1 psiSSX8 Xp11.2 psiSSX8 pseudogene SSX9 Xp11.23 synovial sarcoma, X breakpoint 9 psiSSX9 Xp11.2 SSX9 pseudogene SSX3 Xp11.2-p11.1 synovial sarcoma, X breakpoint 3 SSX4 Xp11.2-p11.1 synovial sarcoma, X breakpoint 4 SLC38A5 Xp11.23 solute carrier family 38, member 5 FTSJ1 Xp11.23 FtsJ homolog 1 (E. coli) PPN Xp11.23 likely ortholog of mouse porcupine homolog (Drosophila) EBP Xp11.23-p11.22 emopamil binding protein (sterol isomerase) OATL1 Xp11.23-p11.22 ornithine aminotransferase-like 1 RBM3 Xp11.23 RNA binding motif protein 3 MRPL32P1 Xq11.23 RNA binding motif protein 3 WDR13 Xp11.23 WD repeat domain 13 WAS Xp11.23-p11.22 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) SUV39H1 Xp11.23 suppressor of variegation 3-9 homolog 1 (Drosophila) LOC392465 X similar to RIKEN cDNA 2010001H14 LOC389854 X similar to Acetyl-coenzyme A acyltransferase 2 GATA1 Xp11.23 GATA binding protein 1 (globin transcription factor 1) HDAC6 Xp11.23 histone deacetylase 6 ERAS Xpter-q26 ES cell expressed Ras PCSK1N Xp11.23 proprotein convertase subtilisin/kexin type 1 inhibitor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1399 26.15 229 - Gure (2002)
8 - 1276 21.53 188 - Gure (2002)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines several types of cancers, i.e. melanoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain related to the KRAB domain of zinc finger proteins at the N terminus
  • a highly acidic C terminus
  • HOMOLOGY
    interspecies homolog to C.elegans w03f8.1
    intraspecies homolog to Krüppel associated box,KRAB
    Homologene
    FAMILY
  • SSX family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as a modulator of transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)(Wu 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene mRNA detect circulating HCC cells as adjuvant diagnostic tool and as indicators of recurrence and prognosis (Wu 2006)
    Marker
    Therapy target
    ANIMAL & CELL MODELS